| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linan Ha, Susan Ceryak, Steven R Patiern. Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. The Journal of biological chemistry. vol 278. issue 20. 2003-06-25. PMID:12637545. |
chromium (vi) activates ataxia telangiectasia mutated (atm) protein. |
2003-06-25 |
2023-08-12 |
Not clear |
| Linan Ha, Susan Ceryak, Steven R Patiern. Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. The Journal of biological chemistry. vol 278. issue 20. 2003-06-25. PMID:12637545. |
the ataxia telangiectasia mutated (atm) protein plays a central role in early stages of dna double strand break (dsb) detection and controls cellular responses to this damage. |
2003-06-25 |
2023-08-12 |
Not clear |
| Kaoru Oguchi, Masatoshi Takagi, Rika Tsuchida, Yoichi Taya, Etsuro Ito, Keiichi Isoyama, Eiichi Ishii, Laura Zannini, Domenico Delia, Shuki Mizutan. Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement. Blood. vol 101. issue 9. 2003-06-20. PMID:12511424. |
the possible involvement of germline mutation of the ataxia telangiectasia mutated (atm) gene in childhood acute leukemia with mixed lineage leukemia (mll) gene rearrangement (mll(+)) was investigated. |
2003-06-20 |
2023-08-12 |
Not clear |
| M Bogliolo, O Cabré, E Callén, V Castillo, A Creus, R Marcos, J Surrallé. The Fanconi anaemia genome stability and tumour suppressor network. Mutagenesis. vol 17. issue 6. 2003-06-17. PMID:12435850. |
fancd2 is independently phosphorylated by atm (the protein whose gene is mutated in ataxia telangiectasia) in response to ionizing radiation. |
2003-06-17 |
2023-08-12 |
Not clear |
| René Daniel, Gary Kao, Konstantin Taganov, James G Greger, Olga Favorova, George Merkel, Tim J Yen, Richard A Katz, Anna Marie Skalk. Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 8. 2003-06-17. PMID:12679521. |
caffeine is an efficient inhibitor of cellular dna repair, likely through its effects on atm (ataxia telangiectasia mutated) and atr (atm and rad3-related) kinases. |
2003-06-17 |
2023-08-12 |
Not clear |
| Takayuki Kobayashi, Shusuke Tada, Takashi Tsuyama, Hiromu Murofushi, Masayuki Seki, Takemi Enomot. Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract. Journal of cell science. vol 115. issue Pt 15. 2003-06-16. PMID:12118071. |
dna replication was almost completely inhibited in the presence of ecori and the inhibition was sensitive to caffeine, an inhibitor of ataxia telangiectasia mutated protein (atm) and atm- and rad3-related protein (atr). |
2003-06-16 |
2023-08-12 |
xenopus_laevis |
| Hai Xiao, Tsai-Kun Li, Jin-Ming Yang, Leroy F Li. Acidic pH induces topoisomerase II-mediated DNA damage. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 9. 2003-06-11. PMID:12692309. |
the following studies in tissue culture models have suggested that acidic ph acts like a top2 poison to induce top2-mediated dna damage: (i) acidic ph induces top2-dependent dna damage signals as evidenced by up-regulation of p53 and ser-139 phosphorylation of h2ax [a substrate for ataxia telangiectasia mutated (atm)atm and rad3-related (atr) kinases]; (ii) acidic ph-induced cytotoxicity in tumor cells is reduced in top2-deficient cells; (iii) acidic ph increases the mutation frequency of the hypoxanthine phosphoribosyl transferase (hprt) gene in a top2-dependent manner; and (iv) acidic ph induces reversible top2-mediated dna strand breaks in vitro. |
2003-06-11 |
2023-08-12 |
mouse |
| Nicole Y Fang, Timothy C Greiner, Dennis D Weisenburger, Wing C Chan, Julie M Vose, Lynette M Smith, James O Armitage, R Aeryn Mayer, Brian L Pike, Francis S Collins, Joseph G Haci. Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 9. 2003-06-11. PMID:12697903. |
mutations have been described in the ataxia telangiectasia mutated (atm) gene in small numbers of cases of lymphoid neoplasia. |
2003-06-11 |
2023-08-12 |
Not clear |
| Alam Nur-E-Kamal, Tsai-Kun Li, Ailing Zhang, Haiyan Qi, Eszter S Hars, Leroy F Li. Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals. The Journal of biological chemistry. vol 278. issue 14. 2003-05-19. PMID:12540848. |
single-stranded dna induces ataxia telangiectasia mutant (atm)/p53-dependent dna damage and apoptotic signals. |
2003-05-19 |
2023-08-12 |
Not clear |
| Alam Nur-E-Kamal, Tsai-Kun Li, Ailing Zhang, Haiyan Qi, Eszter S Hars, Leroy F Li. Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals. The Journal of biological chemistry. vol 278. issue 14. 2003-05-19. PMID:12540848. |
like dna damaging agents, single-stranded dna up-regulated p53 and activated the nuclear kinase ataxia telangiectasia mutant (atm) as evidenced by phosphorylation of histone 2ax, an endogenous atm substrate. |
2003-05-19 |
2023-08-12 |
Not clear |
| Valérie Garcia, Hugues Bruchet, Delphine Camescasse, Fabienne Granier, David Bouchez, Alain Tissie. AtATM is essential for meiosis and the somatic response to DNA damage in plants. The Plant cell. vol 15. issue 1. 2003-05-05. PMID:12509526. |
we previously characterized atatm, an arabidopsis homolog of the human atm gene, which is mutated in ataxia telangiectasia, a chromosome instability disorder. |
2003-05-05 |
2023-08-12 |
human |
| Malcolm R Macleod, Lynne Ramage, Ailsa McGregor, Jonathan R Seck. Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein. Neuroreport. vol 14. issue 2. 2003-04-30. PMID:12598732. |
here we explore a role for ataxia telangiectasia mutated protein (atm), an activator of p53, in a primary cortical culture model of stroke. |
2003-04-30 |
2023-08-12 |
mouse |
| Silvia Saviozzi, Alessandro Saluto, Maria Piane, Sabrina Prudente, Nicola Migone, Mario DeMarchi, Alfredo Brusco, Luciana Chess. Six novel ATM mutations in Italian patients with classical ataxia-telangiectasia. Human mutation. vol 21. issue 4. 2003-04-18. PMID:12655570. |
mutations in the atm gene are responsible for the autosomal recessive syndrome ataxia telangiectasia (at). |
2003-04-18 |
2023-08-12 |
Not clear |
| Sandra Angèle, Anthony Laugé, Marie Fernet, Norman Moullan, Pierre Beauvais, Jérôme Couturier, Dominique Stoppa-Lyonnet, Janet Hal. Phenotypic cellular characterization of an ataxia telangiectasia patient carrying a causal homozygous missense mutation. Human mutation. vol 21. issue 2. 2003-03-26. PMID:12552566. |
most disease-causing mutations in ataxia telangiectasia (at) patients correspond to truncating mutations in the atm gene with very few cases of at patients carrying two missense sequence alterations being reported. |
2003-03-26 |
2023-08-12 |
Not clear |
| T Stankovic, G S Stewart, P Byrd, C Fegan, P A H Moss, A M R Taylo. ATM mutations in sporadic lymphoid tumours. Leukemia & lymphoma. vol 43. issue 8. 2003-03-12. PMID:12400598. |
patients with the autosomal recessive disorder ataxia telangiectasia (a-t) show the biallelic inactivation of the ataxia telangiectasia mutated (atm) gene. |
2003-03-12 |
2023-08-12 |
Not clear |
| Katherine Marcelain, Carmen Luz Navarrete, Mireya Bravo, Manuel Santos, Cecilia Be, Juana Pincheir. [Effect of vitamin E (DL-alpha-tocopherol) on the frequency of chromosomal damage in lymphocytes from patients with ataxia telangiectasia]. Revista medica de Chile. vol 130. issue 9. 2003-02-12. PMID:12434642. |
in ataxia telangiectasia (a-t), the lack of a functional atm kinase is associated with disturbances in the processing of dna damage and a chronic oxidative stress. |
2003-02-12 |
2023-08-12 |
Not clear |
| Konrad S Famulski, Reem S Al-Hijailan, Kelly Dobler, Malgorzata Pienkowska, Futwan Al-Mohanna, Malcolm C Paterso. Aberrant sensing of extracellular Ca2+ by cultured ataxia telangiectasia fibroblasts. Oncogene. vol 22. issue 3. 2003-02-12. PMID:12545170. |
ataxia telangiectasia (at) is a human hereditary syndrome whose underlying gene product, ataxia telangiectasia mutated (atm) protein kinase, is involved in multiple intracellular signaling pathways. |
2003-02-12 |
2023-08-12 |
human |
| Rika Tsuchida, Takayuki Yamada, Masatoshi Takagi, Akira Shimada, Chikashi Ishioka, Yoko Katsuki, Takashi Igarashi, Luciana Chessa, Domenico Delia, Hirobumi Teraoka, Shuki Mizutan. Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast. Radiation research. vol 158. issue 2. 2003-02-06. PMID:12105990. |
a yeast-based frameshift/stop codon assay for examining atm (ataxia telangiectasia mutated) mutations was established. |
2003-02-06 |
2023-08-12 |
human |
| Antonello Giovannetti, Francesca Mazzetta, Elisabetta Caprini, Alessandro Aiuti, Marco Marziali, Marina Pierdominici, Andrea Cossarizza, Luciana Chessa, Enrico Scala, Isabella Quinti, Giandomenico Russo, Massimo Fiorill. Skewed T-cell receptor repertoire, decreased thymic output, and predominance of terminally differentiated T cells in ataxia telangiectasia. Blood. vol 100. issue 12. 2003-01-23. PMID:12393664. |
ataxia telangiectasia (a-t), a genetic disorder caused by the homozygous mutation of the atm gene, frequently associates with variable degrees of cellular and humoral immunodeficiency. |
2003-01-23 |
2023-08-12 |
Not clear |
| Chang Y Guo, David L Brautigan, James M Larne. Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation. The Journal of biological chemistry. vol 277. issue 44. 2003-01-17. PMID:12202491. |
in wild-type jurkat cells or ataxia telangiectasia (at) cells that are stably transfected with full-length atm kinase, ir resulted in net dephosphorylation of this site in pp1 and produced activation of pp1. |
2003-01-17 |
2023-08-12 |
Not clear |