| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E M A Macedo, W C Santos, B P Sousa, E M Lopes, C A Piauilino, F V M Cunha, D P Sousa, F A Oliveira, F R C Almeid. Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 49. issue 7. 2017-05-26. PMID:27332775. |
a possible mechanism of action of the analgesic effect is the involvement of 5-ht2a serotonin receptors, because ketanserin completely reversed the antinociceptive effect of the tpl/dcf association. |
2017-05-26 |
2023-08-13 |
rat |
| Meysam Amidfar, Yong-Ku Kim, Lejla Colic, Mohammad Arbabi, Gholamhossein Mobaraki, Gholamreza Hassanzadeh, Martin Walte. Increased levels of 5HT2A receptor mRNA expression in peripheral blood mononuclear cells of patients with major depression: correlations with severity and duration of illness. Nordic journal of psychiatry. vol 71. issue 4. 2017-05-26. PMID:28125323. |
neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-ht2a and 5-ht3a serotonin receptors in the pathophysiology of major depression. |
2017-05-26 |
2023-08-13 |
Not clear |
| Kendra H Oliver, Matthew T Duvernay, Heidi E Hamm, Ana M D Carneir. Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor. The Journal of biological chemistry. vol 291. issue 38. 2017-05-12. PMID:27422820. |
loss of serotonin transporter function alters adp-mediated glycoprotein αiibβ3 activation through dysregulation of the 5-ht2a receptor. |
2017-05-12 |
2023-08-13 |
mouse |
| Björn Hansson, Anya Medina, Claes Fryklund, Malin Fex, Karin G Stenkul. Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells. Biochemical and biophysical research communications. vol 474. issue 2. 2017-05-10. PMID:27109474. |
serotonin (5-ht) and 5-ht2a receptor agonists suppress lipolysis in primary rat adipose cells. |
2017-05-10 |
2023-08-13 |
rat |
| Dawn Bruijnzeel, Rajiv Tando. Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression. Drug design, development and therapy. vol 10. 2017-05-08. PMID:27274197. |
brexpiprazole is a dopamine d-2 partial agonist with potent activity at the serotonin 5ht1a and 5ht2a and noradrenergic alpha-1b and alpha-2c receptors. |
2017-05-08 |
2023-08-13 |
Not clear |
| Anna Chang, Susan H Fo. Psychosis in Parkinson's Disease: Epidemiology, Pathophysiology, and Management. Drugs. vol 76. issue 11. 2017-04-26. PMID:27312429. |
emerging studies have focused on agents involving other neurotransmitters, including the serotonin 5-ht2a receptor inverse agonist pimavanserin, cholinesterase inhibitors, and antidepressants and anxiolytics. |
2017-04-26 |
2023-08-13 |
Not clear |
| Karolina Pytka, Grzegorz Kazek, Agata Siwek, Barbara Mordyl, Monika Głuch-Lutwin, Anna Rapacz, Adrian Olczyk, Adam Gałuszka, Anna Waszkielewicz, Henryk Marona, Jacek Sapa, Barbara Filipek, Małgorzata Zygmun. HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties. Pharmacology, biochemistry, and behavior. vol 146-147. 2017-04-25. PMID:27132236. |
hbk-7 showed moderate affinity for dopaminergic d2 receptor and very low for serotonergic 5-ht2a, adrenergic α2 receptors, as well as serotonin transporter. |
2017-04-25 |
2023-08-13 |
mouse |
| Anthony Markha. Pimavanserin: First Global Approval. Drugs. vol 76. issue 10. 2017-03-23. PMID:27262680. |
pimavanserin (nuplazid™) is a selective and potent serotonin 2a (5-ht2a) receptor inverse agonist and antagonist developed by acadia pharmaceuticals that has been approved in the us as a treatment for patients with hallucinations and delusions associated with parkinson's disease psychosis. |
2017-03-23 |
2023-08-13 |
Not clear |
| A Gandhimathi, R Sowdhamin. Molecular modelling of human 5-hydroxytryptamine receptor (5-HT2A) and virtual screening studies towards the identification of agonist and antagonist molecules. Journal of biomolecular structure & dynamics. vol 34. issue 5. 2017-02-23. PMID:26327576. |
molecular modelling of human 5-hydroxytryptamine receptor (5-ht2a) and virtual screening studies towards the identification of agonist and antagonist molecules. |
2017-02-23 |
2023-08-13 |
human |
| Xiao-Wen Chen, Yuan-Yuan Sun, Lei Fu, Jian-Qi L. Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27487565. |
a series of novel benzisothiazolylpiperazine derivatives combining potent dopamine d2 and d3, and serotonin 5-ht1a and 5-ht2a receptor properties were synthesized and evaluated for their potential antipsychotic properties. |
2017-02-13 |
2023-08-13 |
rat |
| Donatella Marazziti, Armando Piccinni, Stefano Baroni, Francesco Mungai, Silvio Presta, Federico Mucci, Liliana Dell'Oss. Current Trends on Antipsychotics: Focus on Asenapine. Current medicinal chemistry. vol 23. issue 21. 2017-02-06. PMID:27222264. |
in fact, asenapine shows a high affinity for the serotonin (5ht) receptor of the type 2a (5ht2a) and to a lesser extent for the dopamine receptor of the type 2 (d2), similar to other sgas. |
2017-02-06 |
2023-08-13 |
Not clear |
| Anders Ettrup, Claus Svarer, Brenda McMahon, Sofi da Cunha-Bang, Szabolcs Lehel, Kirsten Møller, Agnete Dyssegaard, Melanie Ganz, Vincent Beliveau, Louise Møller Jørgensen, Nic Gillings, Gitte Moos Knudse. Serotonin 2A receptor agonist binding in the human brain with [(11)C]Cimbi-36: Test-retest reproducibility and head-to-head comparison with the antagonist [(18)F]altanserin. NeuroImage. vol 130. 2017-01-12. PMID:26876490. |
[(11)c]cimbi-36 is a recently developed serotonin 2a (5-ht2a) receptor agonist positron emission tomography (pet) radioligand that has been successfully applied for human neuroimaging. |
2017-01-12 |
2023-08-13 |
human |
| Dubravka Hranilovic, Sofia Blazevic, Jasminka Stefulj, Peter Zil. DNA Methylation Analysis of HTR2A Regulatory Region in Leukocytes of Autistic Subjects. Autism research : official journal of the International Society for Autism Research. vol 9. issue 2. 2017-01-11. PMID:26149086. |
the role of the serotonin receptor 2a (htr2a) in the regulation of central and peripheral serotonin homeostasis, as well as its altered expression in autistic subjects, have implicated the htr2a gene as a major candidate for the serotonin disturbance seen in autism. |
2017-01-11 |
2023-08-13 |
human |
| Julia Brill, Zuoyi Shao, Adam C Puche, Matt Wachowiak, Michael T Shiple. Serotonin increases synaptic activity in olfactory bulb glomeruli. Journal of neurophysiology. vol 115. issue 3. 2017-01-10. PMID:26655822. |
acting through 5ht2a receptors, serotonin (5ht) directly excites external tufted cells (etcs), key excitatory glomerular neurons, and depolarizes some mitral cells (mcs), the olfactory bulb's main output neurons. |
2017-01-10 |
2023-08-13 |
Not clear |
| Stephen M Stah. Mechanism of action of pimavanserin in Parkinson's disease psychosis: targeting serotonin 5HT2A and 5HT2C receptors. CNS spectrums. vol 21. issue 4. 2017-01-06. PMID:27503570. |
mechanism of action of pimavanserin in parkinson's disease psychosis: targeting serotonin 5ht2a and 5ht2c receptors. |
2017-01-06 |
2023-08-13 |
Not clear |
| Stephen M Stah. Mechanism of action of pimavanserin in Parkinson's disease psychosis: targeting serotonin 5HT2A and 5HT2C receptors. CNS spectrums. vol 21. issue 4. 2017-01-06. PMID:27503570. |
pimavanserin, a novel agent approved for the treatment of parkinson's disease psychosis, has potent actions as an antagonist/inverse agonist at serotonin 5ht2a receptors and less potent antagonist/inverse agonist actions at 5ht2c receptors. |
2017-01-06 |
2023-08-13 |
Not clear |
| P Strajhar, Y Schmid, E Liakoni, P C Dolder, K M Rentsch, D V Kratschmar, A Odermatt, M E Liecht. Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects. Journal of neuroendocrinology. vol 28. issue 3. 2016-12-23. PMID:26849997. |
lysergic acid diethylamide (lsd) is a serotonin 5-hydroxytryptamine-2a (5-ht2a ) receptor agonist that is used recreationally worldwide. |
2016-12-23 |
2023-08-13 |
human |
| Manato Kotani, Takeshi Enomoto, Takeshi Murai, Tomokazu Nakako, Yoshihiro Iwamura, Akihiko Kiyoshi, Kenji Matsumoto, Atsushi Matsumoto, Masaru Ikejiri, Tatsuo Nakayama, Yuji Ogi, Kazuhito Iked. The atypical antipsychotic blonanserin reverses (+)-PD-128907- and ketamine-induced deficit in executive function in common marmosets. Behavioural brain research. vol 305. 2016-12-16. PMID:26970575. |
we have previously reported that the atypical antipsychotic blonanserin, a dopamine d2/d3 and serotonin 5-ht2a receptor antagonist, highly occupies dopamine d3 receptors at its antipsychotic dose range in rats. |
2016-12-16 |
2023-08-13 |
rat |
| Helene M Savignac, Yvonne Couch, Michael Stratford, David M Bannerman, George Tzortzis, Daniel C Anthony, Philip W J Burne. Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice. Brain, behavior, and immunity. vol 52. 2016-12-13. PMID:26476141. |
this significant bgos×lps interaction was also observed for 5ht2a receptors, but not for 5ht1a receptors, 5ht, 5hiaa, nmda receptor subunits, or other cytokines. |
2016-12-13 |
2023-08-13 |
mouse |
| Jia Zhou, Kun-kun Geng, Feng-feng Ping, Yue-ying Gao, Lei Liu, Bai-nian Fen. Cross-talk between 5-hydroxytryptamine and substance P in the melanogensis and apoptosis of B16F10 melanoma cells. European journal of pharmacology. vol 775. 2016-12-13. PMID:26872989. |
it has been reported that 5-ht induces melanin synthesis via 5-ht2a receptor. |
2016-12-13 |
2023-08-13 |
Not clear |