| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anette Schrag, Anna Sauerbier, Kallol Ray Chaudhur. New clinical trials for nonmotor manifestations of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 11. 2016-06-09. PMID:26371623. |
large randomized, controlled trials in the last 3 years reported improvement of psychosis with the new selective serotonin 5-ht2a inverse agonist pimavanserin and of postural hypotension with the oral norepinephrine precursor droxidopa. |
2016-06-09 |
2023-08-13 |
Not clear |
| Laura C Sullivan, William P Clarke, Kelly A Ber. Atypical antipsychotics and inverse agonism at 5-HT2 receptors. Current pharmaceutical design. vol 21. issue 26. 2016-06-03. PMID:26044975. |
both the serotonin 5-ht2a and 5-ht2c receptors have demonstrated constitutive receptor activity in vitro and in vivo. |
2016-06-03 |
2023-08-13 |
Not clear |
| Tetsuya Imamura, Osamu Ishizuka, Teruyuki Ogawa, Tomonori Minagawa, Masakuni Ishikawa, Shiro Hiragata, Hitoshi Yokoyama, Masaki Nakazawa, Yoshiki Kurizaki, Osamu Nishizaw. Expression of 5-Hydroxytryptamine Receptors in Human Urinary Bladders with Benign Prostatic Hyperplasia. Advances in therapy. vol 32 Suppl 1. 2016-05-25. PMID:26391373. |
this study investigated the mrna expression pattern and distribution of 5-hydroxytryptamine (5-ht) receptors 5-ht2a, 5-ht2b, 5-ht3a, 5-ht4, and 5-ht7 within the urothelium and detrusor of normal bladder tissue and in the urothelium of bladders from patients with benign prostatic hyperplasia (bph). |
2016-05-25 |
2023-08-13 |
human |
| Fedra Najjar, Thomas Owley, Matthew W Mosconi, Suma Jacob, Kwan Hur, Stephen J Guter, John A Sweeney, Robert D Gibbons, Edwin H Cook, Jeffrey R Bisho. Pharmacogenetic Study of Serotonin Transporter and 5HT2A Genotypes in Autism. Journal of child and adolescent psychopharmacology. vol 25. issue 6. 2016-05-19. PMID:26262902. |
pharmacogenetic study of serotonin transporter and 5ht2a genotypes in autism. |
2016-05-19 |
2023-08-13 |
Not clear |
| Joseph McEvoy, Leslie Citrom. Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator. Clinical schizophrenia & related psychoses. vol 9. issue 4. 2016-05-12. PMID:26757416. |
brexpiprazole acts as a partial agonist at dopamine d2 and serotonin 5-ht1a receptors, and as an antagonist at serotonin 5-ht2a and at adrenergic alpha1b and alpha2c receptors. |
2016-05-12 |
2023-08-13 |
Not clear |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
endogenous 5-ht exerts robust actions on the activity of pyramidal neurons in medial pfc (mpfc) via excitatory 5-ht2a and inhibitory 5-ht1a receptors, suggesting the involvement of 5-ht neurotransmission in cortical functions. |
2016-05-06 |
2023-08-13 |
mouse |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
here we examine the role of 5-ht2a receptors in the processing of emotional and cognitive signals evoked by increasing the 5-ht tone after acute blockade of the 5-ht transporter. |
2016-05-06 |
2023-08-13 |
mouse |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
overall, the present results suggest that 5-ht2a receptors play a detrimental role in long-term memory deficits mediated by an excess 5-ht in pfc. |
2016-05-06 |
2023-08-13 |
mouse |
| Erquan Zhang, Junko Maruyama, Ayumu Yokochi, Yoshihide Mitani, Hirofumi Sawada, Masakatsu Nishikawa, Ning Ma, Kazuo Maruyam. Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. Journal of anesthesia. vol 29. issue 5. 2016-05-05. PMID:25931318. |
sarpogrelate hydrochloride, a serotonin 5ht2a receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. |
2016-05-05 |
2023-08-13 |
rat |
| Erquan Zhang, Junko Maruyama, Ayumu Yokochi, Yoshihide Mitani, Hirofumi Sawada, Masakatsu Nishikawa, Ning Ma, Kazuo Maruyam. Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats. Journal of anesthesia. vol 29. issue 5. 2016-05-05. PMID:25931318. |
the purpose of the present study was to determine if sarpogrelate hydrochloride (spg), a serotonin 5ht2a receptor antagonist, prevented the development of chronic hypoxia-induced pulmonary hypertension (ph) and hypertensive pulmonary vascular remodeling. |
2016-05-05 |
2023-08-13 |
rat |
| Seung-Ah Lee, Jung-Won Suh, Jin Joo Park, Chang-Hwan Yoon, Young-Suk Cho, Tae-Jin Youn, In-Ho Chae, Hyo-Soo Kim, Sang-Hyun Kim, Dong-Ju Cho. Study design of the influence of SErotonin inhibition on patients with RENAl impairment or diabetes undergoing drug-eluting stent implantation (SERENADE) study: A multicenter, open-label, prospective, randomized study. Contemporary clinical trials. vol 43. 2016-05-04. PMID:25891091. |
sarpogrelate, a selective serotonin (5-hydroxytryptamine (ht)2a [5-ht2a]) receptor antagonist, has antiproliferative effects, reducing neointimal hyperplasia and smooth muscle cell proliferation, as well as potent antiplatelet action, inhibiting 5-ht-induced platelet aggregation. |
2016-05-04 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Julia Pintsuk, Thorsten Schäfer, Kristina Friedland, Luca Ferraro, Sergio Tanganelli, Fang Liu, Kjell Fux. Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia. Therapeutic advances in psychopharmacology. vol 6. issue 2. 2016-05-04. PMID:27141290. |
5-hydroxytryptamine 2a (5-ht2a)-d2 heteroreceptor complexes are special targets for atypical antipsychotics with high potency to block their 5-ht2a protomer signaling in view of the potential development of pathological allosteric facilitatory 5-ht2a-d2 interaction increasing d2 protomer signaling. |
2016-05-04 |
2023-08-13 |
Not clear |
| Jingjing Song, Xintong Hou, Xinyu Hu, Chengyu Lu, Chungang Liu, Juan Wang, Wei Liu, Lirong Teng, Di Wan. Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26475043. |
compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-htaa) in serum and hypothalamus, and the reduced expressions of 5-ht1a receptor and 5-ht2a receptor in hypothalamus were observed after af and fluoxetine oral administration indicating that af-mediated antidepressant-like effect may be related to the normalization of serotonergic system. |
2016-05-03 |
2023-08-13 |
rat |
| Rocco A Zoccali, Antonio Bruno, Maria Rosaria Anna Muscatell. Efficacy and safety of sertindole in schizophrenia: a clinical review. Journal of clinical psychopharmacology. vol 35. issue 3. 2016-04-19. PMID:25830594. |
it has a high affinity for dopamine d2, serotonin 5-ht2a and 5-ht2c, and α1 adrenergic receptors. |
2016-04-19 |
2023-08-13 |
Not clear |
| Noelle C Anastasio, Sonja J Stutz, Latham H L Fink, Sarah E Swinford-Jackson, Robert M Sears, Ralph J DiLeone, Kenner C Rice, F Gerard Moeller, Kathryn A Cunningha. Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:26120876. |
serotonin (5-ht) 5-ht2a receptor (5-ht2ar):5-ht2cr imbalance in medial prefrontal cortex associates with motor impulsivity. |
2016-04-19 |
2023-08-13 |
rat |
| Anna Gomółka, Agnieszka Ciesielska, Martyna Z Wróbel, Andrzej Chodkowski, Jerzy Kleps, Maciej Dawidowski, Agata Siwek, Małgorzata Wolak, Katarzyna Stachowicz, Anna Sławińska, Gabriel Nowak, Grzegorz Satała, Andrzej J Bojarski, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Paweł Skowronek, Jadwiga Turło, Franciszek Herol. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5. European journal of medicinal chemistry. vol 98. 2016-04-12. PMID:26043160. |
affinity of the novel pyrido[1,2-c]pyrimidine derivatives for 5-ht1a, 5-ht2a receptors and serotonin transporter (sert) was evaluated in an in vitro radioligand binding assay. |
2016-04-12 |
2023-08-13 |
mouse |
| Xavier Viñals, Estefanía Moreno, Laurence Lanfumey, Arnau Cordomí, Antoni Pastor, Rafael de La Torre, Paola Gasperini, Gemma Navarro, Lesley A Howell, Leonardo Pardo, Carmen Lluís, Enric I Canela, Peter J McCormick, Rafael Maldonado, Patricia Robled. Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. PLoS biology. vol 13. issue 7. 2016-04-12. PMID:26158621. |
cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid cb1 and serotonin 5-ht2a receptors. |
2016-04-12 |
2023-08-13 |
mouse |
| Satoko Baba, Takeshi Enomoto, Tomoko Horisawa, Takashi Hashimoto, Michiko On. Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837930. |
in the present study, we investigated the d3 receptor binding of blonanserin, a dopamine d2/d3 and serotonin 5-ht2a receptors antagonist, in vitro and in vivo. |
2016-04-05 |
2023-08-13 |
human |
| Lijian Ding, Shan He, Wei Wu, Haixiao Jin, Peng Zhu, Jinrong Zhang, Tingting Wang, Ye Yuan, Xiaojun Ya. Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists. Molecules (Basel, Switzerland). vol 20. issue 9. 2016-04-05. PMID:26404234. |
5-hydroxytryptamine type 2a (5-ht2a) receptor is an important target for developing innovative antipsychotic agents in neuropsychiatric disorder therapies. |
2016-04-05 |
2023-08-13 |
Not clear |
| H Bonilla-Jaime, G Guadarrama-Cruz, F J Alarcon-Aguilar, O Limón-Morales, G Vazquez-Palacio. Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. Journal of natural medicines. vol 69. issue 4. 2016-04-01. PMID:26062718. |
the animals were pretreated with a 5-ht1a receptor antagonist (way-100635, 0.5 mg/kg), a 5-ht2a receptor antagonist (ketanserin, 5 mg/kg), a β-noradrenergic receptor antagonist (propranolol, 200 mg/kg), and with a α2-noradrenergic receptor antagonist (yohimbine, 1 mg/kg) alone or combined with the extract and pretreated with a serotonin synthesis inhibitor (pcpa) before treatment with 8-oh-dpat + the extract of t. lucida. |
2016-04-01 |
2023-08-13 |
rat |