| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zofia Rogó. Effect of repeated co-treatment with imipramine and metyrapone on the behavioral reactivity of the central serotonin, dopamine and alpha 1-adrenergic systems in rats. Pharmacological reports : PR. vol 59. issue 5. 2008-11-18. PMID:18048960. |
the aim of present study was to examine the effect of repeated co-treatment with imipramine and metyrapone on the development of adaptive changes in the function of central serotonin 5-ht1a and 5-ht2a, dopamine d2/3 and alpha 1-adrenergic receptors in rats. |
2008-11-18 |
2023-08-12 |
rat |
| A Fabre, J Marchal-Sommé, S Marchand-Adam, C Quesnel, R Borie, M Dehoux, C Ruffié, J Callebert, J-M Launay, D Hénin, P Soler, B Crestan. Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice. The European respiratory journal. vol 32. issue 2. 2008-11-18. PMID:18321937. |
the expression of serotonin receptors 5-ht2a and 5-ht2b increased in the lung after bleomycin treatment, as assessed by pcr, specific binding and immunohistochemistry. |
2008-11-18 |
2023-08-12 |
mouse |
| Maureen L Petrunich, Francisca Garcia, Gonzalo A Carrasco, George Battagli. Prolonged 5-HT1A/5-HT2A receptor cross-talk is absent prior to adulthood in rats. Neuroreport. vol 19. issue 15. 2008-11-03. PMID:18797297. |
in adult rats, serotonin 1a (5-ht1a) receptor activation produces heterologous desensitization of serotonin 2a (5-ht2a) neuroendocrine function at 1 h that persists up to 72 h. this study determined whether prolonged 5-ht1a/5-ht2a cross-talk exists before sexual maturation. |
2008-11-03 |
2023-08-12 |
rat |
| Nobuaki Egashira, Ryoko Okuno, Michihiko Matsushita, Moe Abe, Kenichi Mishima, Katsunori Iwasaki, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwar. Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms. European journal of pharmacology. vol 592. issue 1-3. 2008-10-24. PMID:18644366. |
aripiprazole is a first next-generation atypical antipsychotic drug with dopamine system stabilizing, serotonin (5-hydroxytryptamine, 5-ht) 5-ht1a receptor partial agonistic, and 5-ht2a receptor antagonistic properties. |
2008-10-24 |
2023-08-12 |
mouse |
| Nobuaki Egashira, Katsunori Iwasaki, Ayumi Ishibashi, Kazuhide Hayakawa, Ryoko Okuno, Moe Abe, Naoki Uchida, Kenichi Mishima, Kotaro Takasaki, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwar. Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18558456. |
moreover, abnormalities of the serotonin (5-ht) system such as 5-ht2a receptors have been reported to be associated with bpsd of ad patients. |
2008-10-22 |
2023-08-12 |
mouse |
| Naoko Tanaka, Eisaku Nakamura, Masamichi Ohkura, Masachika Kuwabara, Atsushi Yamashita, Toshio Onitsuka, Yujiro Asada, Hiroaki Hisa, Ryuichi Yamamot. Both 5-hydroxytryptamine 5-HT2A and 5-HT1B receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery. Clinical and experimental pharmacology & physiology. vol 35. issue 7. 2008-10-20. PMID:18430065. |
both 5-hydroxytryptamine 5-ht2a and 5-ht1b receptors are involved in the vasoconstrictor response to 5-ht in the human isolated internal thoracic artery. |
2008-10-20 |
2023-08-12 |
human |
| Brian George Dias, David Crew. Regulation of pseudosexual behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens. Endocrinology. vol 149. issue 9. 2008-10-02. PMID:18483155. |
although 5-ht levels in the vmn do not differ across the ovarian cycle or between hormonally manipulated animals, preov and ovx plus e lizards have a lower abundance of 5-ht2a mrna in the vmn. |
2008-10-02 |
2023-08-12 |
Not clear |
| Y Liu, B L Fanbur. Phospholipase D signaling in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 295. issue 3. 2008-09-30. PMID:18621911. |
inhibition of 5-ht receptor 2a (r 2a) with ketaserin blocked pld activation by 5-ht. |
2008-09-30 |
2023-08-12 |
human |
| L Lattanzi, R Danesi, M Lastella, F Mungai, A Di Paolo, M Tuccori, G B Cassano, M Del Tacc. Serotonin syndrome and the T102-->C polymorphism of the 5-HT2A receptor: a case report. Bipolar disorders. vol 10. issue 5. 2008-09-25. PMID:18657250. |
serotonin syndrome and the t102-->c polymorphism of the 5-ht2a receptor: a case report. |
2008-09-25 |
2023-08-12 |
Not clear |
| Filipe Arantes-Gonçalves, Rui Coelh. [Seeking for biological markers in suicidal behaviour]. Acta medica portuguesa. vol 21. issue 1. 2008-09-18. PMID:18489840. |
on the other hand, genetic polymorphisms of genes like the serotonin transporter, tryptophan hydroxilase and 5-ht2a receptor seem to be significantly associated to suicide. |
2008-09-18 |
2023-08-12 |
human |
| A Kling, M Seddighzadeh, L Arlestig, L Alfredsson, S Rantapää-Dahlqvist, L Padyuko. Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis. Annals of the rheumatic diseases. vol 67. issue 8. 2008-08-11. PMID:18006541. |
genetic variations in the serotonin 5-ht2a receptor gene (htr2a) are associated with rheumatoid arthritis. |
2008-08-11 |
2023-08-12 |
Not clear |
| Dean F Wong, James R Brasić, Harvey S Singer, David J Schretlen, Hiroto Kuwabara, Yun Zhou, Ayon Nandi, Marika A Maris, Mohab Alexander, Weiguo Ye, Olivier Rousset, Anil Kumar, Zsolt Szabo, Albert Gjedde, Anthony A Grac. Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17987065. |
we also measured the brain distribution and bp of serotonin 5-ht2a receptors (5-ht2ar), and serotonin transporter (sert) bp, in 11 subjects with ts and 10 normal control subjects. |
2008-08-07 |
2023-08-12 |
human |
| Chi-Un Pae, Alessandro Serretti, Ashwin A Patkar, Praksh S Masan. Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence. CNS drugs. vol 22. issue 5. 2008-08-01. PMID:18399707. |
such mechanisms include aripiprazole action at serotonin (5-ht) receptors as a 5-ht1a partial receptor agonist, a 5-ht2c partial receptor agonist and a 5-ht2a receptor antagonist. |
2008-08-01 |
2023-08-12 |
Not clear |
| Berna Tander, Sezgin Gunes, Omer Boke, Gamze Alayli, Nurten Kara, Hasan Bagci, Ferhan Cantur. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatology international. vol 28. issue 7. 2008-07-24. PMID:18196244. |
the objective of this study was to determine the potential effects of single nucleotide polymorphisms (snps) in catechol-o-methyltransferase (comt) (rs4680) and 5-hydroxytryptamine (serotonin) 2a (5-ht2a) receptor (rs6313 and rs6311) genes on susceptibility to fms. |
2008-07-24 |
2023-08-12 |
Not clear |
| K A Jennings, W J Sheward, A J Harmar, T Shar. Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function. Neuropharmacology. vol 54. issue 5. 2008-07-17. PMID:18241894. |
evidence that genetic variation in 5-ht transporter expression is linked to changes in 5-ht2a receptor function. |
2008-07-17 |
2023-08-12 |
mouse |
| Ichiro Kusumi, Takuya Masui, Tsukasa Koyam. Long-term perospirone treatment with a single dose at bedtime in schizophrenia: relevant to intermittent dopamine D2 receptor antagonism. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 2. 2008-05-30. PMID:18006133. |
perospirone, a serotonin 5-ht2a and dopamine d2 receptor antagonist, is metabolized to id-15036 by cyp3a4 and the elimination half-life (t1/2) for the latter is longer than the former. |
2008-05-30 |
2023-08-12 |
Not clear |
| Dubravka Hranilović, Ruder Novak, Marina Babić, Mislav Novokmet, Zorana Bujas-Petković, Branimir Jerne. Hyperserotonemia in autism: the potential role of 5HT-related gene variants. Collegium antropologicum. vol 32 Suppl 1. 2008-05-01. PMID:18405062. |
suggested mechanisms for hyperserotonemia in autism have been increased synthesis of serotonin (5ht) by tryptophan hydroxylase (tph), increased uptake into platelets through 5ht transporter (5htt), diminished release from platelets through 5ht2a receptor (5ht2ar) and decreased metabolism by monoamine oxydase (maoa). |
2008-05-01 |
2023-08-12 |
human |
| William E Fantegrossi, Chad J Reissig, Elyse B Katz, Haley L Yarosh, Kenner C Rice, Jerrold C Winte. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17905422. |
hallucinogen-like effects of n,n-dipropyltryptamine (dpt): possible mediation by serotonin 5-ht1a and 5-ht2a receptors in rodents. |
2008-04-09 |
2023-08-12 |
mouse |
| C M Krall, J B Richards, R A Rabin, J C Winte. Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17935763. |
in genetically modified mice lacking the serotonin transporter (sert), 5-ht2a receptor density is decreased and, at a functional level, the head-twitch response following the administration of doi, an index of activation of 5-ht2a receptors, is reduced. |
2008-04-09 |
2023-08-12 |
mouse |
| C J Reissig, J R Eckler, R A Rabin, K C Rice, J C Winte. The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17936346. |
also suggestive of behaviorally relevant interactions between 5-ht1a and 5-ht2a receptors are behavioral analyses of locomotor activity, head-twitch response, forepaw treading and production of the serotonin syndrome; in some instances effects are augmented, in other, diminished. |
2008-04-09 |
2023-08-12 |
rat |