| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriel Araujo Tavares, Amada Torres, Julliet Araujo de Souz. Early Life Stress and the Onset of Obesity: Proof of MicroRNAs' Involvement Through Modulation of Serotonin and Dopamine Systems' Homeostasis. Frontiers in physiology. vol 11. 2020-09-28. PMID:32848865. |
the first pieces of evidence highlight the presence of the mir-16 in the regulation of the serotonin transporter (sert) as well as the receptors 1a (5ht1a) and 2a (5ht2a). |
2020-09-28 |
2023-08-13 |
Not clear |
| Nicholas Zareifopoulos, Maria Lagadinou, Anastasia Karela, Ourania Kyriakopoulou, Dimitrios Velissari. Neuropsychiatric Effects of Antiviral Drugs. Cureus. vol 12. issue 8. 2020-09-28. PMID:32905132. |
the pathogenetic mechanisms may involve molecular targets common to other centrally active drugs, including human monoamine oxidase-a (mao-a), serotonin receptors, gamma-aminobutyric acid (gaba) gaba-a receptors, 5-ht2a and 5-ht2c receptors and others. |
2020-09-28 |
2023-08-13 |
human |
| Christoph U Correl. Current Treatment Options and Emerging Agents for Schizophrenia. The Journal of clinical psychiatry. vol 81. issue 3. 2020-09-14. PMID:32297721. |
mechanisms of action that are under investigation include dopamine d3 antagonism/serotonin 5-ht1a partial agonism; combined dopamine, serotonin, and glutamate modulation; phosphodiesterase 10a inhibition; trace amine-associated receptor-1 (taar1) agonism plus 5-ht1a agonism; 5-ht2a inverse agonism; sigma-2/5-ht2a antagonism; d-amino acid oxidase (daao) inhibition; glycine transporter-1 inhibition; vesicular monoamine transporter-2 antagonism; mu opioid antagonism added to olanzapine; and novel long-acting injectable antipsychotic formulations. |
2020-09-14 |
2023-08-13 |
Not clear |
| Betina Elfving, Heidi Kaastrup Müller, Ignasi Oliveras, Tina Becher Østerbøg, Cristobal Rio-Alamos, Ana Sanchez-Gonzalez, Adolf Tobeña, Alberto Fernandez-Teruel, Susana Azna. Differential expression of synaptic markers regulated during neurodevelopment in a rat model of schizophrenia-like behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-28. PMID:31228641. |
the inbred roman high- (rha-i) and low- (rla-i) avoidance rat strains are a congenital neurobehavioral model, with the rha-i displaying schizophrenia-related behaviors and serotonin 2a (5-ht2a) and metabotropic glutamate 2 (mglu2) receptor alterations in the prefrontal cortex (pfc). |
2020-08-28 |
2023-08-13 |
rat |
| María E Terrón-Díaz, Sara J Wright, Melina A Agosto, Olivier Lichtarge, Theodore G Wense. Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. The Journal of biological chemistry. vol 294. issue 50. 2020-07-13. PMID:31676688. |
the d2 dopamine receptor and the serotonin 5-hydroxytryptamine 2a receptor (5-ht2a) are closely-related g-protein-coupled receptors (gpcrs) from the class a bioamine subfamily. |
2020-07-13 |
2023-08-13 |
Not clear |
| Henry A Nasrallah, Rissa Fedora, Robert Morto. Successful treatment of clozapine-nonresponsive refractory hallucinations and delusions with pimavanserin, a serotonin 5HT-2A receptor inverse agonist. Schizophrenia research. vol 208. 2020-07-02. PMID:30837203. |
one such possible agent is the non-dopaminergic antipsychotic pimavanserin, an inverse agonist of serotonin 5-ht2a receptors which was recently approved for the hallucinations and delusions of parkinson's disease psychosis. |
2020-07-02 |
2023-08-13 |
Not clear |
| Mariama Jaiteh, Ismael Rodríguez-Espigares, Jana Selent, Jens Carlsso. Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity. PLoS computational biology. vol 16. issue 3. 2020-06-29. PMID:32168319. |
homology models of the d2 dopamine (d2r) and serotonin 5-ht2a receptors (5-ht2ar) were generated based on crystal structures of 16 different gpcrs. |
2020-06-29 |
2023-08-13 |
Not clear |
| Akinori Y Sato, Keisuke Tsunoda, Ryo Mizuyama, Satoshi Shimeg. Serotonin improves behavioral contrast sensitivity of freely moving rats. PloS one. vol 15. issue 3. 2020-06-23. PMID:32191757. |
our previous study demonstrated the visual responses of neurons in the primary visual cortex (v1) of anesthetized monkeys were modulated by the activation of 5-ht receptors depending on the response magnitude, in which 5-ht2a receptor-selective agonists enhanced weak visual responses but not strong responses. |
2020-06-23 |
2023-08-13 |
rat |
| Louisa J. Steinberg, Mark D. Underwood, Mihran J. Bakalian, Suham A. Kassir, J. John Mann, Victoria Arang. 5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression Journal of psychiatry & neuroscience : JPN. vol 44. issue 5. 2020-06-22. PMID:31120232. |
5-ht1a receptor, 5-ht2a receptor and serotonin transporter binding in the human auditory cortex in depression serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. |
2020-06-22 |
2023-08-13 |
human |
| John Wesson Ashfor. Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions. Journal of Alzheimer's disease : JAD. vol 67. issue 3. 2020-06-01. PMID:30776014. |
trazodone has a variety of effects on several monoaminergic mechanisms: a potent serotonin 5-ht2a and α1-adrenergic receptor antagonist, a weak serotonin reuptake inhibitor, and a weak antihistamine or histamine h1 receptor inverse agonist. |
2020-06-01 |
2023-08-13 |
human |
| Coralie Berthoux, Alexander Barre, Joël Bockaert, Philippe Marin, Carine Bécame. Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-05-22. PMID:29917056. |
among the 5-ht receptors abundantly expressed in pfc, 5-ht2a receptors located in dendrites of layer v pyramidal neurons control neuronal excitability and mediate the psychotropic effects of psychedelic hallucinogens, but their impact on glutamatergic transmission and synaptic plasticity remains poorly characterized. |
2020-05-22 |
2023-08-13 |
mouse |
| Coralie Berthoux, Alexander Barre, Joël Bockaert, Philippe Marin, Carine Bécame. Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-05-22. PMID:29917056. |
here, we show that a 20-min exposure of mouse pfc slices to serotonin or the 5-ht2a receptor agonist 2,5-dimethoxy-4-iodoamphetamine (doi) produces a long-lasting depression of evoked ampa excitatory postsynaptic currents in layer v pyramidal neurons. |
2020-05-22 |
2023-08-13 |
mouse |
| Vanshika Sinh, Youichirou Ootsuk. Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice. The journal of physiological sciences : JPS. vol 69. issue 6. 2020-05-11. PMID:31432430. |
this study determined whether blockade of 5-hydroxytryptamine 2a (5-ht2a) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. |
2020-05-11 |
2023-08-13 |
mouse |
| Gregory M James, Gregor Gryglewski, Thomas Vanicek, Neydher Berroterán-Infante, Cécile Philippe, Alexander Kautzky, Lukas Nics, Chrysoula Vraka, Godber M Godbersen, Jakob Unterholzner, Helen L Sigurdardottir, Marie Spies, René Seiger, Georg S Kranz, Andreas Hahn, Markus Mitterhauser, Wolfgang Wadsak, Andreas Bauer, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberge. Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 1. 2020-03-03. PMID:30357321. |
positron emission tomography was carried out for the quantification of serotonin 1a (5-ht1a, n = 30) and 5-ht2a receptors (n = 22), the serotonin-degrading enzyme monoamine oxidase a (mao-a, n = 32) and the serotonin transporter (5-htt, n = 24) in healthy participants. |
2020-03-03 |
2023-08-13 |
human |
| Kevin Sean Murnan. Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder. Behavioural pharmacology. vol 30. issue 2 and 3-Spec Issue. 2020-01-06. PMID:30632995. |
the 2a subtype of serotonin receptors (5-ht2a receptor) is the major excitatory serotonin receptor in the brain and has been linked to the effects of drugs that produce profound sensory and cognitive changes. |
2020-01-06 |
2023-08-13 |
Not clear |
| Frederick S Barrett, Katrin H Preller, Marcus Herdener, Petr Janata, Franz X Vollenweide. Serotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 11. 2019-12-20. PMID:29028939. |
classic psychedelic drugs (serotonin 2a, or 5ht2a, receptor agonists) have notable effects on music listening. |
2019-12-20 |
2023-08-13 |
Not clear |
| Hadeel M Abdelrahman, Laila M Sherief, Ashgan A Alghobashy, Sanaa M Abdel Salam, Haitham M Hashim, Nelly R Abdel Fattah, Randa H Mohame. Association of 5-HT2A receptor gene polymorphisms with gastrointestinal disorders in Egyptian children with autistic disorder. Research in developmental disabilities. vol 36C. 2019-11-20. PMID:25462508. |
we aimed to investigate whether there were any association between the -1438a/g, 102t/c and his452tyr polymorphisms of the serotonin 2a receptor gene (5-ht2a) in egyptian children with asd and gid. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tatsuya Ishii, Yasuyuki Kimura, Masanori Ichise, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Manabu Kubota, Ming-Rong Zhang, Makiko Yamada, Makoto Higuchi, Yoshiro Okubo, Tetsuya Suhar. Correction: Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. PloS one. vol 13. issue 5. 2019-11-20. PMID:29734370. |
correction: anatomical relationships between serotonin 5-ht2a and dopamine d2 receptors in living human brain. |
2019-11-20 |
2023-08-13 |
human |
| María Rodríguez-Muñoz, Pilar Sánchez-Blázquez, Javier Garzó. Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. vol 9. issue 34. 2019-11-20. PMID:29805740. |
fenfluramine diminishes nmda receptor-mediated seizures via its mixed activity at serotonin 5ht2a and type 1 sigma receptors. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ana Flávia Belchior de Andrade, Jose Gonzalez-Rodrigue. Electroanalytical identification of 25I-NBOH and 2C-I via differential pulse voltammetry: a rapid and sensitive screening method to avoid misidentification. The Analyst. vol 144. issue 9. 2019-11-20. PMID:30839986. |
25i-nboh is a new potent serotonin 5-ht2a receptor agonist recently identified in blotter paper seizures. |
2019-11-20 |
2023-08-13 |
Not clear |