| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carey Y L Huh, Marc Danik, Frédéric Manseau, Louis-Eric Trudeau, Sylvain William. Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 6. 2008-02-25. PMID:18256260. |
these results demonstrate a previously unidentified role of ngf and its receptor p75(ntr); their interactions are crucial for cholinergic and glutamatergic transmission in the septohippocampal pathway. |
2008-02-25 |
2023-08-12 |
rat |
| O Schulte-Herbrüggen, U Hamker, V Meske, H Danker-Hopfe, T G Ohm, R Hellwe. Beta/A4-Amyloid increases nerve growth factor production in rat primary hippocampal astrocyte cultures. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 25. issue 6. 2008-02-19. PMID:17646078. |
nerve growth factor (ngf), a member of the neurotrophin family, is an essential mediator of neuronal activity and synaptic plasticity of basal forebrain cholinergic neurons (bfcn). |
2008-02-19 |
2023-08-12 |
rat |
| Elliott J Mufson, Scott E Counts, Margaret Fahnestock, Stephen D Ginsber. Cholinotrophic molecular substrates of mild cognitive impairment in the elderly. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908035. |
cholinergic nucleus basalis (nb) neurons provide the major cholinergic innervation to the cortical mantle, are selectively vulnerable in late stage alzheimer's disease (ad) and require the neurotrophin, nerve growth factor (ngf) and its receptors (trka and p75(ntr)), for their survival. |
2008-02-01 |
2023-08-12 |
human |
| A C Cuello, M A Bruno, K F S Bel. NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908036. |
forebrain cholinergic neurons are highly dependent on nerve growth factor (ngf) for phenotype maintenance. |
2008-02-01 |
2023-08-12 |
mouse |
| A C Cuello, M A Bruno, K F S Bel. NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908036. |
we have established that in addition to "target-derived" ngf neurotrophic stimulation, cholinergic neurons also respond dose-dependently, to intra-parenchymal ngf administration in the somato-dendritic region of the nucleus basalis, thus illustrating the potential of alternative reparative therapies which would by-pass the undesirable effects of diffuse neurotrophin application. |
2008-02-01 |
2023-08-12 |
mouse |
| A C Cuello, M A Bruno, K F S Bel. NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908036. |
moreover, our lab has also observed that the steady-state number of cortical cholinergic synapses is dependent on continuous ngf supply, as anti-ngf monoclonal antibodies and trka receptor antagonists deplete pre-existing cholinergic bouton numbers. |
2008-02-01 |
2023-08-12 |
mouse |
| A C Cuello, M A Bruno, K F S Bel. NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908036. |
furthermore, the application of either ngf or trka ngf-mimetic agonists successfully rescues the age-dependent loss of cortical cholinergic boutons in aged-impaired rats. |
2008-02-01 |
2023-08-12 |
mouse |
| A C Cuello, M A Bruno, K F S Bel. NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908036. |
given that prongf is known to be upregulated in ad patients a dysregulation in the maturation or degradation of mature ngf might explain the preferential vulnerability of the cholinergic system in the ad pathology. |
2008-02-01 |
2023-08-12 |
mouse |
| Francesco Angelucci, Valerio Ricci, Massimiliano Pomponi, Gianluigi Conte, Aleksander A Mathé, Pietro Attilio Tonali, Pietro Bri. Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. Journal of psychopharmacology (Oxford, England). vol 21. issue 8. 2008-01-29. PMID:17715210. |
in particular, nerve growth factor (ngf) plays an important role in the survival and function of cholinergic neurons while brain-derived neurotrophic factor (bdnf) is involved in synaptic plasticity and in the maintenance of midbrain dopaminergic and cholinergic neurons. |
2008-01-29 |
2023-08-12 |
human |
| Ezio Giacobini, Robert E Becke. One hundred years after the discovery of Alzheimer's disease. A turning point for therapy? Journal of Alzheimer's disease : JAD. vol 12. issue 1. 2007-12-17. PMID:17851193. |
based on experimental evidence that ngf (nerve growth factor) treatment could provide prolonged protection of the central cholinergic system, i.c.v. |
2007-12-17 |
2023-08-12 |
Not clear |
| E T Ang, F Gomez-Pinill. Potential therapeutic effects of exercise to the brain. Current medicinal chemistry. vol 14. issue 24. 2007-11-28. PMID:17979709. |
ngf and bdnf) and their receptors, some pro-inflammatory cytokines (l-1beta, il-6, tnf-alpha, ifn-gamma), microglia and astrocytes, and the cholinergic neuronal cells in the forebrain. |
2007-11-28 |
2023-08-12 |
Not clear |
| Bianxiao Cui, Chengbiao Wu, Liang Chen, Alfredo Ramirez, Elaine L Bearer, Wei-Ping Li, William C Mobley, Steven Ch. One at a time, live tracking of NGF axonal transport using quantum dots. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 34. 2007-10-19. PMID:17698956. |
retrograde axonal transport of nerve growth factor (ngf) signals is critical for the survival, differentiation, and maintenance of peripheral sympathetic and sensory neurons and basal forebrain cholinergic neurons. |
2007-10-19 |
2023-08-12 |
rat |
| V Sposato, L Manni, G N Chaldakov, L Alo. Streptozotocin-induced diabetes is associated with changes in NGF levels in pancreas and brain. Archives italiennes de biologie. vol 145. issue 2. 2007-08-21. PMID:17639781. |
ngf plays an important role during brain development and may be able to delay or even reverse damaged forebrain cholinergic neurons that undergo degeneration in aged animals and in alzheimer's disease (ad). |
2007-08-21 |
2023-08-12 |
rat |
| V Sposato, L Manni, G N Chaldakov, L Alo. Streptozotocin-induced diabetes is associated with changes in NGF levels in pancreas and brain. Archives italiennes de biologie. vol 145. issue 2. 2007-08-21. PMID:17639781. |
given the importance of ngf in the pathophysiology of brain cholinergic neurons, we looked for ngf changes in the pancreas and brain of diabetic rats. |
2007-08-21 |
2023-08-12 |
rat |
| A Claudio Cuello, Martin A Brun. The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochemical research. vol 32. issue 6. 2007-08-01. PMID:17404842. |
the failure in ngf maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in alzheimer's disease. |
2007-08-01 |
2023-08-12 |
Not clear |
| A Claudio Cuello, Martin A Brun. The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochemical research. vol 32. issue 6. 2007-08-01. PMID:17404842. |
this short review discusses the arguments to consider the dismetabolism of the pathway responsible for both the maturation and degradation of ngf as the culprit of vulnerability of the forebrain cholinergic system to the alzheimer's disease neuropathology. |
2007-08-01 |
2023-08-12 |
Not clear |
| A Claudio Cuello, Martin A Brun. The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochemical research. vol 32. issue 6. 2007-08-01. PMID:17404842. |
this metabolic scenario in alzheimer's disease should result in the failure of ngf trophic support to forebrain cholinergic neurons and thus explaining the vulnerability of these neurons in this neurodegenerative condition. |
2007-08-01 |
2023-08-12 |
Not clear |
| Mats Nilbratt, Linda Friberg, Malahat Mousavi, Amelia Marutle, Agneta Nordber. Retinoic acid and nerve growth factor induce differential regulation of nicotinic acetylcholine receptor subunit expression in SN56 cells. Journal of neuroscience research. vol 85. issue 3. 2007-05-14. PMID:17203487. |
in the present study, we characterized the expression of different nicotinic acetylcholine receptor (nachr) subtypes in the cholinergic sn56 cell line and investigated the roles of ra and ngf in the expression of choline acetyltransferase (chat) and different nachr subtypes. |
2007-05-14 |
2023-08-12 |
Not clear |
| Mats Nilbratt, Linda Friberg, Malahat Mousavi, Amelia Marutle, Agneta Nordber. Retinoic acid and nerve growth factor induce differential regulation of nicotinic acetylcholine receptor subunit expression in SN56 cells. Journal of neuroscience research. vol 85. issue 3. 2007-05-14. PMID:17203487. |
the present results show that ra and ngf have different effects on the expression of chat and the morphology and the expression pattern of different nachr subunits in cholinergic sn56 cells. |
2007-05-14 |
2023-08-12 |
Not clear |
| Helena Frielingsdorf, Daniel R Simpson, Leon J Thal, Donald P Pizz. Nerve growth factor promotes survival of new neurons in the adult hippocampus. Neurobiology of disease. vol 26. issue 1. 2007-05-08. PMID:17270453. |
to investigate whether ngf-dependent cognitive improvement may be due in part to increased hippocampal neurogenesis, adult and aged male rats were treated with ngf or vehicle intracerebroventricularly for 6 or 20 days followed by evaluation of cholinergic parameters and hippocampal neurogenesis. |
2007-05-08 |
2023-08-12 |
rat |