| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helena Frielingsdorf, Daniel R Simpson, Leon J Thal, Donald P Pizz. Nerve growth factor promotes survival of new neurons in the adult hippocampus. Neurobiology of disease. vol 26. issue 1. 2007-05-08. PMID:17270453. |
we show that ngf increases hippocampal cholinergic activity as rapidly as 3 days after initiation of treatment. |
2007-05-08 |
2023-08-12 |
rat |
| Helena Frielingsdorf, Daniel R Simpson, Leon J Thal, Donald P Pizz. Nerve growth factor promotes survival of new neurons in the adult hippocampus. Neurobiology of disease. vol 26. issue 1. 2007-05-08. PMID:17270453. |
taken together, these findings suggest that ngf, likely mediated through increased cholinergic tone, promotes neurogenesis in the adult hippocampus, which may relate to the nootropic action of ngf. |
2007-05-08 |
2023-08-12 |
rat |
| Simona Capsoni, Antonino Cattane. On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer's disease. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16944323. |
the neurotrophin nerve growth factor (ngf) promotes survival and differentiation of basal forebrain cholinergic neurons. |
2007-04-24 |
2023-08-12 |
mouse |
| Brice Williams, Ann-Charlotte Granholm, Kumar Sambamurt. Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation. Neuroscience letters. vol 413. issue 2. 2007-04-11. PMID:17182181. |
the loss of nerve growth factor (ngf) and its high affinity receptor trka has been implicated in the loss of cholinergic tone and function in alzheimer's disease (ad) and normal aging. |
2007-04-11 |
2023-08-12 |
rat |
| Karma V Moser, Petra Stöckl, Christian Humpe. Cholinergic neurons degenerate when exposed to conditioned medium of primary rat brain capillary endothelial cells: counteraction by NGF, MK-801 and inflammation. Experimental gerontology. vol 41. issue 6. 2007-04-10. PMID:16701975. |
cholinergic neurons degenerate when exposed to conditioned medium of primary rat brain capillary endothelial cells: counteraction by ngf, mk-801 and inflammation. |
2007-04-10 |
2023-08-12 |
rat |
| Karma V Moser, Petra Stöckl, Christian Humpe. Cholinergic neurons degenerate when exposed to conditioned medium of primary rat brain capillary endothelial cells: counteraction by NGF, MK-801 and inflammation. Experimental gerontology. vol 41. issue 6. 2007-04-10. PMID:16701975. |
the aim of this study was to observe, if brain capillary endothelial cells (bcec) may produce and secrete factors which induce cell death of cholinergic neurons, and if this effect is counteracted by (1) ngf, mk-801 or vitamin c, (2) modulated by experimentally-induced inflammation with interleukin-1beta and lipopolysaccharide (il-1beta and lps) or (3) by blocking of different intracellular signalling pathways. |
2007-04-10 |
2023-08-12 |
rat |
| Alessandro Lambiase, Lucia Pagani, Veronica Di Fausto, Valentina Sposato, Marco Coassin, Stefano Bonini, Luigi Alo. Nerve growth factor eye drop administrated on the ocular surface of rodents affects the nucleus basalis and septum: biochemical and structural evidence. Brain research. vol 1127. issue 1. 2007-03-09. PMID:17113055. |
time-course studies revealed that repeated ngf application leads to high concentration of this neurotrophins after 6 h and normal levels after 24 h. our results also showed that topical eye application of ngf causes an enhanced expression of ngf receptors and chat immunoreactivity in forebrain cholinergic neurons, suggesting that ocular ngf application could have a functional role on damaged brain cells. |
2007-03-09 |
2023-08-12 |
rat |
| G Niewiadomska, M Baksalerska-Pazera, A Gasiorowska, A Mietelsk. Nerve growth factor differentially affects spatial and recognition memory in aged rats. Neurochemical research. vol 31. issue 12. 2007-02-09. PMID:17111224. |
in rats, object discrimination depends on the integrity of the cholinergic system, thus it could be expected that nerve growth factor (ngf) can improve the behavior in aged subjects. |
2007-02-09 |
2023-08-12 |
human |
| C A Gericke, O Schulte-Herbrüggen, T Arendt, R Hellwe. Chronic alcohol intoxication in rats leads to a strong but transient increase in NGF levels in distinct brain regions. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 7. 2007-01-05. PMID:16252071. |
nerve growth factor (ngf), a member of the neurotrophin family, is an essential mediator of neuronal activity and synaptic plasticity of basal forebrain cholinergic neurons. |
2007-01-05 |
2023-08-12 |
rat |
| C A Gericke, O Schulte-Herbrüggen, T Arendt, R Hellwe. Chronic alcohol intoxication in rats leads to a strong but transient increase in NGF levels in distinct brain regions. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 7. 2007-01-05. PMID:16252071. |
6-month alcohol treatment led to an increase of ngf to 650-850% of controls in the basal forebrain and the septum and to a 210-485% increase in the cholinergic projection areas (anterior cortex, hippocampus and olfactory bulb). |
2007-01-05 |
2023-08-12 |
rat |
| Michael Pirchl, Josef Marksteiner, Christian Humpe. Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease. Neurological research. vol 28. issue 6. 2006-10-19. PMID:16945219. |
cholinergic neurons incubated in medium ph 6.0 degenerated within 2-3 days and were not rescued by nerve growth factor (ngf). |
2006-10-19 |
2023-08-12 |
Not clear |
| Alvin V Terry, Vinay Parikh, Debra A Gearhart, Anilkumar Pillai, Elizabeth Hohnadel, Samantha Warner, Henry A Nasrallah, Sahebarao P Mahadi. Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in rats. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16702442. |
in this rodent study, we evaluated the effects of different time periods (7, 14, 45, and 90 days) of oral treatment with haloperidol (hal; 2.0 mg/kg/day) or ziprasidone (zip; 12.0 mg/kg/day) on nerve growth factor (ngf) and choline acetyltransferase (chat) levels in the hippocampus, and we subsequently assessed water maze task performance, prepulse inhibition (ppi) of the auditory gating response, and several ngf-related proteins and cholinergic markers after 90 days of treatment. |
2006-08-31 |
2023-08-12 |
human |
| Alvin V Terry, Vinay Parikh, Debra A Gearhart, Anilkumar Pillai, Elizabeth Hohnadel, Samantha Warner, Henry A Nasrallah, Sahebarao P Mahadi. Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in rats. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16702442. |
these data support the premise that, although zip (given chronically) seems somewhat superior to hal due to less pronounced behavioral effects and a more delayed appearance of neurochemical deficits, both antipsychotics produce time-dependent deleterious effects on ngf, cholinergic markers (i.e., important neurobiological substrates of memory), and cognitive function. |
2006-08-31 |
2023-08-12 |
human |
| Ahmad Salehi, Jean-Dominique Delcroix, Pavel V Belichenko, Ke Zhan, Chengbiao Wu, Janice S Valletta, Ryoko Takimoto-Kimura, Alexander M Kleschevnikov, Kumar Sambamurti, Peter P Chung, Weiming Xia, Angela Villar, William A Campbell, Laura Shapiro Kulnane, Ralph A Nixon, Bruce T Lamb, Charles J Epstein, Gorazd B Stokin, Lawrence S B Goldstein, William C Moble. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. vol 51. issue 1. 2006-08-31. PMID:16815330. |
because of evidence suggesting that the ngf transport defect was intra-axonal, we explored within cholinergic axons the status of early endosomes (ees). |
2006-08-31 |
2023-08-12 |
mouse |
| Ahmad Salehi, Jean-Dominique Delcroix, Pavel V Belichenko, Ke Zhan, Chengbiao Wu, Janice S Valletta, Ryoko Takimoto-Kimura, Alexander M Kleschevnikov, Kumar Sambamurti, Peter P Chung, Weiming Xia, Angela Villar, William A Campbell, Laura Shapiro Kulnane, Ralph A Nixon, Bruce T Lamb, Charles J Epstein, Gorazd B Stokin, Lawrence S B Goldstein, William C Moble. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. vol 51. issue 1. 2006-08-31. PMID:16815330. |
our study thus provides evidence for a pathogenic mechanism for ds in which increased expression of app, in the context of trisomy, causes abnormal transport of ngf and cholinergic neurodegeneration. |
2006-08-31 |
2023-08-12 |
mouse |
| Mee-Sook Song, Lucila Saavedra, Elena I Posse de Chave. Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Abeta in distal axons. Neurobiology of aging. vol 27. issue 9. 2006-08-28. PMID:16122841. |
in agreement with previous suggestions that disruption of nerve growth factor (ngf)-mediated signaling might contribute to the loss of cholinergic neurons, we found that provision of ngf to cell bodies protects sympathetic neurons from abeta-induced apoptosis. |
2006-08-28 |
2023-08-12 |
rat |
| Christine Seitz McCauslin, Victoria Heath, Anna Maria Colangelo, Radek Malik, Sook Lee, Alessandra Mallei, Italo Mocchetti, Peter F Johnso. CAAT/enhancer-binding protein delta and cAMP-response element-binding protein mediate inducible expression of the nerve growth factor gene in the central nervous system. The Journal of biological chemistry. vol 281. issue 26. 2006-08-18. PMID:16632469. |
because ngf is a crucial neurotrophic factor for basal forebrain cholinergic neurons, defining the mechanisms that regulate its transcription is important for developing therapeutic strategies to treat pathologies of these neurons. |
2006-08-18 |
2023-08-12 |
mouse |
| Nicola Origlia, Simona Capsoni, Luciano Domenici, Antonino Cattane. Time window in cholinomimetic ability to rescue long-term potentiation in neurodegenerating anti-nerve growth factor mice. Journal of Alzheimer's disease : JAD. vol 9. issue 1. 2006-07-28. PMID:16627935. |
ad11 transgenic mice producing blocking antibodies against nerve growth factor (ngf) are characterized by a progressive neurodegenerative phenotype defined by the deposition of amyloid peptide, intracellular neurofibrillary tangles and by a marked cholinergic depletion. |
2006-07-28 |
2023-08-12 |
mouse |
| Z-X Wu, R D De. Nerve growth factor-enhanced airway responsiveness involves substance P in ferret intrinsic airway neurons. American journal of physiology. Lung cellular and molecular physiology. vol 291. issue 1. 2006-07-25. PMID:16461428. |
however, constrictive response to cholinergic agonist was not significantly altered between the ngf treatment group and the control group. |
2006-07-25 |
2023-08-12 |
Not clear |
| Birgit Zassler, Christian Humpe. Transplantation of NGF secreting primary monocytes counteracts NMDA-induced cell death of rat cholinergic neurons in vivo. Experimental neurology. vol 198. issue 2. 2006-06-09. PMID:16443222. |
transplantation of ngf secreting primary monocytes counteracts nmda-induced cell death of rat cholinergic neurons in vivo. |
2006-06-09 |
2023-08-12 |
rat |