| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Birgit Zassler, Christian Humpe. Transplantation of NGF secreting primary monocytes counteracts NMDA-induced cell death of rat cholinergic neurons in vivo. Experimental neurology. vol 198. issue 2. 2006-06-09. PMID:16443222. |
the aim of the present study was to observe, if transplanted primary monocytes secreting ngf may counteract n-methyl-d-aspartate (nmda)-induced cell death of cholinergic neurons of the basal nucleus of meynert (nbm) in vivo. |
2006-06-09 |
2023-08-12 |
rat |
| C M Hernandez, D A Gearhart, V Parikh, E J Hohnadel, L W Davis, M L Middlemore, S P Warsi, J L Waller, A V Terr. Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16214877. |
this study was designed to determine 1) whether repeated exposures to the acetylcholinesterase inhibitors (acheis) galantamine (gal) or donepezil (don) resulted in positive effects on nerve growth factor (ngf) and its receptors, cholinergic proteins, and cognitive function in the aged rat, and 2) whether gal had any advantages over don given its allosteric potentiating ligand (apl) activity at nicotinic acetylcholine receptors. |
2006-04-04 |
2023-08-12 |
rat |
| Helena Frielingsdorf, Leon J Thal, Donald P Pizz. The septohippocampal cholinergic system and spatial working memory in the Morris water maze. Behavioural brain research. vol 168. issue 1. 2006-04-04. PMID:16330106. |
in the third phase, intracerebroventricular infusions of nerve growth factor (ngf) were employed to enhance cholinergic activity of the unlesioned rats and potentially further separate group performance. |
2006-04-04 |
2023-08-12 |
rat |
| Chia-wen K Wu, Hermes H Ye. Nerve growth factor rapidly increases muscarinic tone in mouse medial septum/diagonal band of Broca. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 17. 2006-03-09. PMID:15858049. |
in this study, we investigated the effect of acute ngf exposure on neurons in the mouse medial septum/diagonal band of broca (ms/db), focusing on the cholinergic neurons and the subpopulation of noncholinergic neurons that were identified to be putatively gabaergic. |
2006-03-09 |
2023-08-12 |
mouse |
| Chia-wen K Wu, Hermes H Ye. Nerve growth factor rapidly increases muscarinic tone in mouse medial septum/diagonal band of Broca. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 17. 2006-03-09. PMID:15858049. |
however, focal application of ngf to individual ms/db neurons increased spontaneous firing in cholinergic, but not in the noncholinergic, subpopulation. |
2006-03-09 |
2023-08-12 |
mouse |
| Ke Wu, Edwin M Meyer, Jennifer A Bennett, Craig A Meyers, Jeffrey A Hughes, Michael A Kin. AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy. Brain research. vol 1061. issue 2. 2006-01-17. PMID:16226726. |
aav2/5-mediated ngf gene delivery protects septal cholinergic neurons following axotomy. |
2006-01-17 |
2023-08-12 |
Not clear |
| Ke Wu, Edwin M Meyer, Jennifer A Bennett, Craig A Meyers, Jeffrey A Hughes, Michael A Kin. AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy. Brain research. vol 1061. issue 2. 2006-01-17. PMID:16226726. |
however, both types of vector provided similar levels of long-term (17 weeks) protection of septal cholinergic neurons from axotomy and led to similar levels of ngf accumulation in this region. |
2006-01-17 |
2023-08-12 |
Not clear |
| Brice Williams, Matthew Nelson, Ann-Charlotte Granholm, Steve Coultrap, Michael Browning, Maria Curti. Altered NGF response but not release in the aged septo-hippocampal cholinergic system. Experimental neurology. vol 196. issue 1. 2005-11-22. PMID:16137678. |
altered ngf response but not release in the aged septo-hippocampal cholinergic system. |
2005-11-22 |
2023-08-12 |
human |
| Brice Williams, Matthew Nelson, Ann-Charlotte Granholm, Steve Coultrap, Michael Browning, Maria Curti. Altered NGF response but not release in the aged septo-hippocampal cholinergic system. Experimental neurology. vol 196. issue 1. 2005-11-22. PMID:16137678. |
an important aspect of aging and alzheimer's disease (ad) pathology includes the degeneration of basal forebrain cholinergic neurons (bfcns), possibly due to disrupted nerve growth factor (ngf) signaling. |
2005-11-22 |
2023-08-12 |
human |
| Brice Williams, Matthew Nelson, Ann-Charlotte Granholm, Steve Coultrap, Michael Browning, Maria Curti. Altered NGF response but not release in the aged septo-hippocampal cholinergic system. Experimental neurology. vol 196. issue 1. 2005-11-22. PMID:16137678. |
since cholinergic degeneration coupled with altered levels of ngf and trka receptors are also seen in human aging and ad, the loss of acute responsivity to ngf in the bfcns may also play a role in these processes. |
2005-11-22 |
2023-08-12 |
human |
| Allison D Ebert, Clive N Svendse. A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy. Rejuvenation research. vol 8. issue 3. 2005-10-20. PMID:16144466. |
nerve growth factor (ngf) is the archetypical protein discovered in the 1960s that is able to both increase survival and functioning of cholinergic neurons. |
2005-10-20 |
2023-08-12 |
Not clear |
| Armin Blesch, James Conner, Alexander Pfeifer, Mehdi Gasmi, Anthony Ramirez, William Britton, Ron Alfa, Inder Verma, Mark H Tuszynsk. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 11. issue 6. 2005-10-06. PMID:15922962. |
regulated lentiviral ngf gene transfer controls rescue of medial septal cholinergic neurons. |
2005-10-06 |
2023-08-12 |
human |
| Armin Blesch, James Conner, Alexander Pfeifer, Mehdi Gasmi, Anthony Ramirez, William Britton, Ron Alfa, Inder Verma, Mark H Tuszynsk. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 11. issue 6. 2005-10-06. PMID:15922962. |
nerve growth factor (ngf) has been shown to promote survival and function of cholinergic neurons in the basal forebrain in various models of neuronal degeneration in rodents and primates. |
2005-10-06 |
2023-08-12 |
human |
| Armin Blesch, James Conner, Alexander Pfeifer, Mehdi Gasmi, Anthony Ramirez, William Britton, Ron Alfa, Inder Verma, Mark H Tuszynsk. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 11. issue 6. 2005-10-06. PMID:15922962. |
we examined whether a regulatable in vivo expression system can control the survival of cholinergic neurons after injury, using a tetracycline-regulated promoter ("tet-off" system) to modulate lentiviral ngf gene delivery. |
2005-10-06 |
2023-08-12 |
human |
| Armin Blesch, James Conner, Alexander Pfeifer, Mehdi Gasmi, Anthony Ramirez, William Britton, Ron Alfa, Inder Verma, Mark H Tuszynsk. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Molecular therapy : the journal of the American Society of Gene Therapy. vol 11. issue 6. 2005-10-06. PMID:15922962. |
two weeks after lesions to cholinergic neurons, significant cell rescue (65+/-8% neuron survival; p<0.005 compared to controls) was observed when ngf expression was activated. |
2005-10-06 |
2023-08-12 |
human |
| Susan H Bora, Zhiping Liu, Aleksandar Kecojevic, Istvan Merchenthaler, Vassilis E Koliatso. Direct, complex effects of estrogens on basal forebrain cholinergic neurons. Experimental neurology. vol 194. issue 2. 2005-09-15. PMID:15893308. |
in parallel, we study the hippocampal expression of ngf, bdnf, and nt-3, i.e., neurotrophins with known trophic roles on cholinergic neurons. |
2005-09-15 |
2023-08-12 |
mouse |
| Manuel M Paula-Barbosa, Pedro A Pereira, Armando Cardoso, M Dulce Madeira, António Cadete-Leit. The effects of nerve growth factor upon the neuropeptide content of the suprachiasmatic nucleus of rats withdrawn from ethanol are mediated by the nucleus basalis magnocellularis. Journal of neurocytology. vol 33. issue 4. 2005-08-31. PMID:15520530. |
because scn neurons do not express trka, ngf might have exerted its effects either through direct signalling of the neurons via p75ntr or by enhancing the activity of the cholinergic afferents to the scn, which arise from the nucleus basalis magnocellularis (nbm). |
2005-08-31 |
2023-08-12 |
rat |
| b' Francesco Angelucci, Luigi Aloe, Patricia Jim\\xc3\\xa9nez-Vasquez, Aleksander A Math\\xc3\\xa. Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression. The international journal of neuropsychopharmacology. vol 6. issue 3. 2005-07-18. PMID:12974988.' |
nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) are proteins involved in neuronal survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in the central nervous system. |
2005-07-18 |
2023-08-12 |
rat |
| Hyemyung Seo, Ole Isacso. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869949. |
at this age, both ts65dn mice and their lm abnormally responded to cholinergic muscarinic m1 agonist treatment in terms of hippocampal app, nerve growth factor (ngf), and brain-derived neurotrophic factor (bdnf) levels compared to young adult c57bl/6 mice. |
2005-07-15 |
2023-08-12 |
mouse |
| Mark H Tuszynski, Leon Thal, Mary Pay, David P Salmon, Hoi Sang U, Roy Bakay, Piyush Patel, Armin Blesch, H Lee Vahlsing, Gilbert Ho, Gang Tong, Steven G Potkin, James Fallon, Lawrence Hansen, Elliott J Mufson, Jeffrey H Kordower, Christine Gall, James Conne. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nature medicine. vol 11. issue 5. 2005-07-12. PMID:15852017. |
nerve growth factor (ngf) stimulates cholinergic function, improves memory and prevents cholinergic degeneration in animal models of injury, amyloid overexpression and aging. |
2005-07-12 |
2023-08-12 |
human |