| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Francesco Angelucci, Luigi Aloe, Angela Iannitelli, Susanne H M Gruber, Aleksander A Math\\xc3\\xa. Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 15. issue 3. 2005-06-08. PMID:15820421.' |
since ngf and bdnf are involved in the regulation of cholinergic, dopaminergic and serotonergic neurons in the central nervous system (cns) we hypothesized that chronic olanzapine treatment will influence the distribution of ngf and bdnf in the rat brain. |
2005-06-08 |
2023-08-12 |
rat |
| Scott E Counts, Elliott J Mufso. The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease. Journal of neuropathology and experimental neurology. vol 64. issue 4. 2005-05-24. PMID:15835262. |
dysfunction of nerve growth factor (ngf) and its high (trka) and low (p75ntr) affinity receptors has been suggested to underlie the selective degeneration of the nucleus basalis (nb) cholinergic cortical projection neurons in end stage alzheimer disease (ad). |
2005-05-24 |
2023-08-12 |
Not clear |
| Martin A Bruno, Paul B S Clarke, Alicia Seltzer, Rémi Quirion, Kevin Burgess, A Claudio Cuello, H Uri Saragov. Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 37. 2005-05-17. PMID:15371501. |
here, the in vivo efficacy of d3 as a potential therapeutic for cholinergic neurons was tested in cognitively impaired aged rats, and we compared the consequence of partial trka activation (d3) versus full trka/p75 activation (ngf). |
2005-05-17 |
2023-08-12 |
rat |
| C M Hernandez, A V Terr. Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor. Neuroscience. vol 130. issue 4. 2005-05-11. PMID:15652996. |
however, to date, comprehensive studies of nicotine's effects on the expression of specific acetylcholine (ach) receptor subtypes, key cholinergic proteins (that are regulated by ngf) such as choline acetyltransferase (chat) and the vesicular ach transporter (vacht) are lacking. |
2005-05-11 |
2023-08-12 |
rat |
| C M Hernandez, A V Terr. Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor. Neuroscience. vol 130. issue 4. 2005-05-11. PMID:15652996. |
these results suggest that repeated exposure to nicotine results in positive effects on central cholinergic markers and memory function, which may be mediated via effects on high-affinity ngf receptors. |
2005-05-11 |
2023-08-12 |
rat |
| Ray D Beck, Michael A King, Grace K Ha, Jesse D Cushman, Zhi Huang, John M Petitt. IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710467. |
to extend our previous findings, several experiments were conducted comparing il-2 ko mice and wild-type littermates to determine (1) whether the gabaergic projection neurons of il-2 ko mice in this region were also affected; (2) if the reduction in septal cholinergic projection neurons found in adult il-2 ko mice is present at weaning (and prior to the development of peripheral autoimmune disease); and (3) if loss of il-2 may result in changes in the neurotrophins, brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf), involved in maintenance of hippocampal neurons. |
2005-04-28 |
2023-08-12 |
mouse |
| B Zassler, G Dechant, C Humpe. Urea enhances the nerve growth factor-induced neuroprotective effect on cholinergic neurons in organotypic rat brain slices. Neuroscience. vol 130. issue 2. 2005-04-25. PMID:15664688. |
a high number of cholinergic neurons survived in the presence of 0.1-100 ng/ml ngf. |
2005-04-25 |
2023-08-12 |
rat |
| B Zassler, G Dechant, C Humpe. Urea enhances the nerve growth factor-induced neuroprotective effect on cholinergic neurons in organotypic rat brain slices. Neuroscience. vol 130. issue 2. 2005-04-25. PMID:15664688. |
incubation of brain slices with ngf + urea + l-thiocitrulline did not further enhance the number of cholinergic neurons. |
2005-04-25 |
2023-08-12 |
rat |
| Roberta De Rosa, Addys Ancheta Garcia, Chiara Braschi, Simona Capsoni, Lamberto Maffei, Nicoletta Berardi, Antonino Cattane. Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 10. 2005-04-07. PMID:15728733. |
we previously showed that intranasal administration of ngf determined an amelioration of cholinergic deficit and a decrease in the number of phosphotau-positive neurons and of beta-amyloid accumulation in ad11 mice, which express transgenic antibodies neutralizing ngf action and exhibit a progressive alzheimer-like neurodegeneration. |
2005-04-07 |
2023-08-12 |
mouse |
| Beata Madziar, Ignacio Lopez-Coviella, Victoria Zemelko, Brygida Bers. Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol-3'-kinase pathway. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686478. |
nerve growth factor (ngf) exerts anti-apoptotic, trophic and differentiating actions on sympathetic neurons and cholinergic cells of the basal forebrain and activates the expression of genes regulating the synthesis and storage of the neurotransmitter acetylcholine (ach). |
2005-03-21 |
2023-08-12 |
mouse |
| A Lin, S Lourenssen, R D P Stanzel, M G Blennerhasset. Selective loss of NGF-sensitive neurons following experimental colitis. Experimental neurology. vol 191. issue 2. 2005-02-18. PMID:15649490. |
the distribution of expression of neural phenotypes among the ngf receptor-expressing population was differentially affected by inflammation, with selective decrease among cholinergic excitatory neurons and calbindin-expressing neurons, and a trend to increase among inhibitory nitrergic neurons. |
2005-02-18 |
2023-08-12 |
rat |
| Thomas Debeir, M Marien, J Ferrario, P Rizk, A Prigent, F Colpaert, R Raisman-Vozar. In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530877. |
in vivo upregulation of endogenous ngf in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. |
2004-12-29 |
2023-08-12 |
rat |
| Thomas Debeir, M Marien, J Ferrario, P Rizk, A Prigent, F Colpaert, R Raisman-Vozar. In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530877. |
since nerve growth factor (ngf) is critical to the survival of nbm cholinergic neurons in the adult brain and its synthesis is known to be regulated by noradrenergic mechanisms, we examined whether the protective effect of dexefaroxan in the devascularization model was associated with regional induction of ngf biosynthesis. |
2004-12-29 |
2023-08-12 |
rat |
| Thomas Debeir, M Marien, J Ferrario, P Rizk, A Prigent, F Colpaert, R Raisman-Vozar. In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530877. |
in dexefaroxan-treated devascularized rats, increases in ngf protein levels (2-fold) and immunoreactivity were maintained in both the cortex and nbm over the entire 28-day postoperation period; these increases were coincident with changes in functional markers characteristic of ngf's actions, including increases in choline acetyltransferase (chat), p75 and trka immunoreactivities, and a preservation of nbm cholinergic cell numbers. |
2004-12-29 |
2023-08-12 |
rat |
| Thomas Debeir, M Marien, J Ferrario, P Rizk, A Prigent, F Colpaert, R Raisman-Vozar. In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530877. |
dexefaroxan also increased ngf protein levels in sham-operated rats, but without any significant consequence to the otherwise normal nbm cholinergic phenotype in these animals. |
2004-12-29 |
2023-08-12 |
rat |
| Thomas Debeir, M Marien, J Ferrario, P Rizk, A Prigent, F Colpaert, R Raisman-Vozar. In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530877. |
results indicate that activation of endogenous ngf systems could contribute to the cholinergic protective effect of dexefaroxan in the cortical devascularization model, and provide further support for a potential therapeutic utility of dexefaroxan in neurodegenerative diseases where central cholinergic function is progressively compromised. |
2004-12-29 |
2023-08-12 |
rat |
| Andrzej Szutowicz, Beata Madziar, Tadeusz Pawełczyk, Maria Tomaszewicz, Hanna Bielarczy. Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287901. |
effects of ngf on acetylcholine, acetyl-coa metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. |
2004-10-28 |
2023-08-12 |
Not clear |
| Andrzej Szutowicz, Beata Madziar, Tadeusz Pawełczyk, Maria Tomaszewicz, Hanna Bielarczy. Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287901. |
the aim of this work was to explain mechanisms of the positive and negative effects of ngf on phenotypic properties and viability of cholinergic cells. |
2004-10-28 |
2023-08-12 |
Not clear |
| Andrzej Szutowicz, Beata Madziar, Tadeusz Pawełczyk, Maria Tomaszewicz, Hanna Bielarczy. Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287901. |
to discriminate these effects we used two p75ntr receptor-positive lines of cholinergic neuroblastoma cells, sn56 and t17 that are devoid of or express high affinity ngf (trka) receptors, respectively. |
2004-10-28 |
2023-08-12 |
Not clear |
| Andrzej Szutowicz, Beata Madziar, Tadeusz Pawełczyk, Maria Tomaszewicz, Hanna Bielarczy. Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287901. |
on the contrary, in both camp/all-trans-retinoic acid (ra) differentiated cell lines, ngf resulted in a similar suppression of cholinergic phenotype along with an increase of mitochondrial acetyl-coa and cell susceptibility to nitric oxide and amyloid-beta25-35. |
2004-10-28 |
2023-08-12 |
Not clear |