| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrzej Szutowicz, Beata Madziar, Tadeusz Pawełczyk, Maria Tomaszewicz, Hanna Bielarczy. Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287901. |
data indicate that: (i) positive cholinotrophic effects of ngf required activation of both trka and p75ntr receptors; (ii) camp/ra-evoked differentiation inhibited ngf effects mediated by trka receptors and activated its p75ntr-dependent suppressing influences and (iii) a differentiation-evoked decrease of mitochondrial acetyl-coa and an elevation of mitochondrial ca could augment impairment of cholinergic neurons by neurotoxic signals. |
2004-10-28 |
2023-08-12 |
Not clear |
| Steven T DeKosky, Eric E Abrahamson, Kevin M Taffe, C Edward Dixon, Patrick M Kochanek, Milos D Ikonomovi. Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287906. |
infusion of ngf in injured, hypothermia-treated animals was ineffective in restoring hippocampal antioxidant enzymes activity to levels produced after injury under normothermic conditions, although it was able to increase septal cholinergic (choline acetyltransferase) enzyme activity. |
2004-10-28 |
2023-08-12 |
rat |
| Ke Wu, Craig A Meyers, Nicole K Guerra, Michael A King, Edwin M Meye. The effects of rAAV2-mediated NGF gene delivery in adult and aged rats. Molecular therapy : the journal of the American Society of Gene Therapy. vol 9. issue 2. 2004-09-17. PMID:14759810. |
we also showed that ngf gene transfer into the septum of aged animals induced local trophic effects by increasing the number and soma area of septal cholinergic neurons and improved distal synaptic activity by increasing the level of depolarization-induced acetylcholine (ach) release from hippocampal synaptic terminals. |
2004-09-17 |
2023-08-12 |
mouse |
| Klaus Heese, Noriko Inoue, Yasuo Nagai, Tohru Sawad. APP, NGF & the 'Sunday-driver' in a Trolley on the Road. Restorative neurology and neuroscience. vol 22. issue 2. 2004-09-09. PMID:15272147. |
this interest is based on the observation that cbf neurons, which provide the major source of cholinergic innervation to the cerebral cortex and hippocampus, undergo selective and severe degeneration in advanced ad and that the survival of cbf neurons depends upon ngf and its receptors, namely, trka and p75ntr. |
2004-09-09 |
2023-08-12 |
Not clear |
| Tetsuji Mori, Zhang Yuxing, Hiromi Takaki, Mayumi Takeuchi, Ken Iseki, Seita Hagino, Jun-ichi Kitanaka, Motohiko Takemura, Hidemi Misawa, Masahito Ikawa, Masaru Okabe, Akio Wanak. The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. The European journal of neuroscience. vol 19. issue 12. 2004-08-18. PMID:15217369. |
in these mice, cells expressing cholinergic neuron markers, such as choline acetyltransferase, vesicular acetylcholine transporter and p75 low-affinity ngf receptor, were markedly reduced in the basal forebrain, whereas other cholinergic neurons including brain stem and spinal motor neurons expressed the markers. |
2004-08-18 |
2023-08-12 |
mouse |
| Ke Wu, Craig A Meyers, Jennifer A Bennett, Michael A King, Edwin M Meyer, Jeffrey A Hughe. Polyethylenimine-mediated NGF gene delivery protects transected septal cholinergic neurons. Brain research. vol 1008. issue 2. 2004-07-21. PMID:15145767. |
polyethylenimine-mediated ngf gene delivery protects transected septal cholinergic neurons. |
2004-07-21 |
2023-08-12 |
mouse |
| Ke Wu, Craig A Meyers, Jennifer A Bennett, Michael A King, Edwin M Meyer, Jeffrey A Hughe. Polyethylenimine-mediated NGF gene delivery protects transected septal cholinergic neurons. Brain research. vol 1008. issue 2. 2004-07-21. PMID:15145767. |
to investigate whether pei-mediated nerve growth factor (ngf) gene transfer protected axotomized septal cholinergic neurons, we injected linear pei (in vivo jetpei, qbiogene) complexed with a plasmid encoding for mouse ngf (pei/pngf-w) into the rat septum. |
2004-07-21 |
2023-08-12 |
mouse |
| Shiyong Peng, Joanne Wuu, Elliott J Mufson, Margaret Fahnestoc. Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease. Journal of neuropathology and experimental neurology. vol 63. issue 6. 2004-07-08. PMID:15217092. |
nerve growth factor (ngf) is critical for the regulation, differentiation, and survival of basal forebrain cholinergic neurons that degenerate in the late stage of alzheimer disease (ad). |
2004-07-08 |
2023-08-12 |
human |
| Heidi S Phillips, Merry Nishimura, Mark P Armanini, Karen Chen, Kathryn M Albers, Brian M Davi. Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance. Brain research. Molecular brain research. vol 124. issue 1. 2004-06-28. PMID:15093680. |
rescue of ngf-deficient mice ii: basal forebrain cholinergic projections require ngf for target innervation but not guidance. |
2004-06-28 |
2023-08-12 |
mouse |
| Heidi S Phillips, Merry Nishimura, Mark P Armanini, Karen Chen, Kathryn M Albers, Brian M Davi. Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance. Brain research. Molecular brain research. vol 124. issue 1. 2004-06-28. PMID:15093680. |
basal forebrain cholinergic (bfc) neurons are an important substrate of cognitive function and are hypothesized to require the presence of nerve growth factor (ngf) for survival and target innervation. |
2004-06-28 |
2023-08-12 |
mouse |
| Heidi S Phillips, Merry Nishimura, Mark P Armanini, Karen Chen, Kathryn M Albers, Brian M Davi. Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance. Brain research. Molecular brain research. vol 124. issue 1. 2004-06-28. PMID:15093680. |
surprisingly, intracerebroventricular infusion of ngf into juvenile mice can induce an essentially normal pattern of cholinergic innervation of the hippocampus. |
2004-06-28 |
2023-08-12 |
mouse |
| D P Pizzo, L J Tha. Intraparenchymal nerve growth factor improves behavioral deficits while minimizing the adverse effects of intracerebroventricular delivery. Neuroscience. vol 124. issue 4. 2004-06-08. PMID:15026115. |
nerve growth factor (ngf) delivered via intracerebroventricular (icv) infusion restores behavioral and biochemical deficits in animal models of cholinergic hypofunction. |
2004-06-08 |
2023-08-12 |
Not clear |
| D P Pizzo, L J Tha. Intraparenchymal nerve growth factor improves behavioral deficits while minimizing the adverse effects of intracerebroventricular delivery. Neuroscience. vol 124. issue 4. 2004-06-08. PMID:15026115. |
the goal of the study was to determine whether direct infusion of ngf would result in a more restricted topographical distribution of ngf leading to a reduction or elimination of the adverse events while still augmenting cholinergic functioning sufficiently to restore spatial mnemonic processing. |
2004-06-08 |
2023-08-12 |
Not clear |
| Ke Wu, Ronald L Klein, Craig A Meyers, Michael A King, Jeffrey A Hughes, Williams J Millard, Edwin M Meye. Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum. Human gene therapy. vol 14. issue 15. 2004-06-02. PMID:14577926. |
although ngf gene therapy has been proposed to treat age- or disease-related brain cholinergic decline, little is known about the ectopic expression or function of this trophic factor after transduction in the brain especially over long intervals. |
2004-06-02 |
2023-08-12 |
mouse |
| Ke Wu, Ronald L Klein, Craig A Meyers, Michael A King, Jeffrey A Hughes, Williams J Millard, Edwin M Meye. Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum. Human gene therapy. vol 14. issue 15. 2004-06-02. PMID:14577926. |
ngf gene transfer attenuated the lesion-induced loss of septal cholinergic but not gabaergic neurons, indicating that long-term expression did not eliminate this response, which has been noted over short intervals. |
2004-06-02 |
2023-08-12 |
mouse |
| Ke Wu, Ronald L Klein, Craig A Meyers, Michael A King, Jeffrey A Hughes, Williams J Millard, Edwin M Meye. Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum. Human gene therapy. vol 14. issue 15. 2004-06-02. PMID:14577926. |
ngf transduction increased cholinergic cell size in the septum, but required a higher vector dose than neuroprotection. |
2004-06-02 |
2023-08-12 |
mouse |
| Russell W Brown, Kenyatta D Thompson, Kimberly N Thompson, J Jeffrey Ward, Stephanie K Thacker, Michael T Williams, Richard M Kostrzew. Adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expression. The European journal of neuroscience. vol 19. issue 6. 2004-05-28. PMID:15066159. |
the results of this investigation demonstrate that long-term increases in dopamine d(2) receptor sensitivity produce significant decreases in hippocampal cholinergic and ngf expression that may result in cognitive impairment. |
2004-05-28 |
2023-08-12 |
rat |
| Christine Erhardt, Rodrigue Galani, Hélène Jeltsch, Jean-Christophe Cassel, Paul Klosen, Jérôme S Menet, Paul Pévet, Etienne Challe. Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor. The European journal of neuroscience. vol 19. issue 7. 2004-05-24. PMID:15078551. |
when injected in the scn, this immunotoxin destroys the cholinergic projections and retinohypothalamic afferents that express p75 low-affinity nerve growth factor (p75(ngf)) receptors. |
2004-05-24 |
2023-08-12 |
rat |
| Christine Erhardt, Rodrigue Galani, Hélène Jeltsch, Jean-Christophe Cassel, Paul Klosen, Jérôme S Menet, Paul Pévet, Etienne Challe. Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor. The European journal of neuroscience. vol 19. issue 7. 2004-05-24. PMID:15078551. |
the intra-scn treatment reduced light-induced phase advances by 30%, and induced a complete loss of forebrain and retinal afferents expressing p75(ngf) receptors within the scn and a decrease of forebrain cholinergic neurons, most likely those projecting to the scn. |
2004-05-24 |
2023-08-12 |
rat |
| Christine Erhardt, Rodrigue Galani, Hélène Jeltsch, Jean-Christophe Cassel, Paul Klosen, Jérôme S Menet, Paul Pévet, Etienne Challe. Modulation of photic resetting in rats by lesions of projections to the suprachiasmatic nuclei expressing p75 neurotrophin receptor. The European journal of neuroscience. vol 19. issue 7. 2004-05-24. PMID:15078551. |
because the integrity of forebrain p75(ngf)-expressing neurons appears to be critical in mediating the effects on light-induced phase advances, we therefore suggest that anterior cholinergic projections expressing p75(ngf) receptors modulate the sensitivity of the scn clock to the phase advancing effects of light. |
2004-05-24 |
2023-08-12 |
rat |