| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajapaksha Gedara Prasad Tharanga Jayasooriya, Yung Hyun Choi, Gi-Young Ki. Glutamine-free condition inhibits lipopolysaccharide-induced invasion of BV2 microglial cells by suppressing of matrix metalloproteinase-9 expression. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24177576. |
studies showing the mechanisms involved in glutamine (gln) starvation and regulation of matrix metalloproteinase-9 (mmp-9) expression in microglia are rare, even though mmp-9 plays a crucial role in the proinflammatory microenvironment by degrading the blood-brain barrier. |
2014-07-15 |
2023-08-12 |
Not clear |
| Katyayni Vinnakota, Feng Hu, Min-Chi Ku, Petya B Georgieva, Frank Szulzewsky, Andreas Pohlmann, Sonia Waiczies, Helmar Waiczies, Thoralf Niendorf, Seija Lehnardt, Uwe-Karsten Hanisch, Michael Synowitz, Darko Markovic, Susanne A Wolf, Rainer Glass, Helmut Kettenman. Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. Neuro-oncology. vol 15. issue 11. 2014-06-17. PMID:24014382. |
we have previously shown that microglia promote glioma expansion through upregulation of membrane type 1 matrix metalloprotease (mt1-mmp). |
2014-06-17 |
2023-08-12 |
Not clear |
| Cláudia Caldeira, Ana F Oliveira, Carolina Cunha, Ana R Vaz, Ana S Falcão, Adelaide Fernandes, Dora Brite. Microglia change from a reactive to an age-like phenotype with the time in culture. Frontiers in cellular neuroscience. vol 8. 2014-06-11. PMID:24917789. |
in contrast, 16 div (aged) microglia evidenced ramified morphology and increased matrix metalloproteinase (mmp)-2 activation, as well as reduced mmp-9, glutamate release and nuclear factor kappa-b activation, in parallel with decreased expression of toll-like receptor (tlr)-2 and tlr-4, capacity to migrate and phagocytose. |
2014-06-11 |
2023-08-13 |
mouse |
| Sun Young Park, Se Jin Park, Tae Gyeong Park, Seetharaman Rajasekar, Sang-Joon Lee, Young-Whan Cho. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia. International immunopharmacology. vol 17. issue 2. 2014-04-22. PMID:23859871. |
in microglia, schizandrin c significantly inhibited lipoteichoic acid (lta)-stimulated pro-inflammatory cytokines and chemokines, prostaglandin e2 (pge2), nitric oxide (no), and reactive oxygen species (ros) production, and inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), and matrix metallopeptidase-9 (mmp-9) protein expressions. |
2014-04-22 |
2023-08-12 |
Not clear |
| Makoto Tsuda, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. P2X4 receptors and neuropathic pain. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24191146. |
those include the cc chemokine ccl21 derived from damaged neurons, the extracellular matrix protein fibronectin in the spinal cord, and the transcription factor interferon regulatory factor 8 (irf8) expressed in microglia. |
2014-03-25 |
2023-08-12 |
Not clear |
| Diego Clemente, María Cristina Ortega, Carolina Melero-Jerez, Fernando de Castr. The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases. Frontiers in cellular neuroscience. vol 7. 2014-03-10. PMID:24391545. |
in the present work, we review the specific interactions between opcs and other glial cells (astrocytes, microglia) during cns development and in the pathological scenario of ms. we focus on: (i) the role of astrocytes in maintaining the homeostasis and spatial distribution of different secreted cues that determine opc proliferation, migration, and differentiation during cns development; (ii) the role of microglia and astrocytes in the redistribution of iron, which is crucial for myelin synthesis during cns development and for myelin repair in ms; (iii) how microglia secrete different molecules, e.g., growth factors, that favor the recruitment of opcs in acute phases of ms lesions; and (iv) how astrocytes modify the extracellular matrix in ms lesions, affecting the ability of opcs to attempt spontaneous remyelination. |
2014-03-10 |
2023-08-12 |
Not clear |
| Manuel J Rodríguez, Margot Martínez-Moreno, Francisco J Ortega, Nicole Mah. Targeting microglial K(ATP) channels to treat neurodegenerative diseases: a mitochondrial issue. Oxidative medicine and cellular longevity. vol 2013. 2014-02-19. PMID:23844272. |
in a dynamic equilibrium with the lesion microenvironment, microglia phenotypes cover from a proinflammatory activation state to a neurotrophic one directly involved in cell repair and extracellular matrix remodeling. |
2014-02-19 |
2023-08-12 |
Not clear |
| Helen Könnecke, Ingo Bechman. The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas. Clinical & developmental immunology. vol 2013. 2014-02-17. PMID:24023566. |
the role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas. |
2014-02-17 |
2023-08-12 |
Not clear |
| Aleksandra Ellert-Miklaszewska, Michal Dabrowski, Maciej Lipko, Marcin Sliwa, Marta Maleszewska, Bozena Kaminsk. Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia. Glia. vol 61. issue 7. 2014-02-10. PMID:23650109. |
gliomas attract microglia and polarize them into tumor-supporting cells that participate in matrix remodeling, invasion, angiogenesis, and suppression of adaptive immunity. |
2014-02-10 |
2023-08-12 |
rat |
| Sun Young Park, Se Jin Park, Nan Jeong Park, Woo Hong Joo, Sang-Joon Lee, Young-Whan Cho. α-Iso-cubebene exerts neuroprotective effects in amyloid beta stimulated microglia activation. Neuroscience letters. vol 555. 2014-01-31. PMID:24090820. |
microglia that are stimulated by amyloid β increased their production of pro-inflammatory cytokines and chemokines, prostaglandin e2 (pge2), nitric oxide (no) and reactive oxygen species (ros) and the enzymatic activity of matrix metalloproteinase 9 (mmp-9). |
2014-01-31 |
2023-08-12 |
Not clear |
| Evon S Ereifej, Mark Ming-Cheng Cheng, Guangzhao Mao, Pamela J VandeVor. Examining the inflammatory response to nanopatterned polydimethylsiloxane using organotypic brain slice methods. Journal of neuroscience methods. vol 217. issue 1-2. 2014-01-13. PMID:23660527. |
a long-term effect of chronically implanted neural electrodes is the formation of a glial scar made up of reactive astrocytes, microglia and the matrix proteins they generate. |
2014-01-13 |
2023-08-12 |
Not clear |
| Kumiko Ijichi, Graham D Brown, Craig S Moore, Jean-Pyo Lee, Paige N Winokur, Roberto Pagarigan, Evan Y Snyder, Ernesto R Bongarzone, Stephen J Crocke. MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology. Glia. vol 61. issue 5. 2013-12-16. PMID:23404611. |
here we report that exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase (mmp)-3 that mediated a morphological transformation of microglia into a multinucleated globoid cell type. |
2013-12-16 |
2023-08-12 |
mouse |
| Thomas Blank, Marco Prin. Microglia as modulators of cognition and neuropsychiatric disorders. Glia. vol 61. issue 1. 2013-09-04. PMID:22740320. |
microglia critically contribute to cns homeostasis by their actions in phagocytosis of cellular debris, release of a variety of cell signaling factors including neurotrophins and extracellular matrix components and direct contact with neurons. |
2013-09-04 |
2023-08-12 |
Not clear |
| Smriti M Agrawal, Jacqueline Williamson, Ritu Sharma, Hania Kebir, Kamala Patel, Alexandre Prat, V Wee Yon. Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis. Brain : a journal of neurology. vol 136. issue Pt 6. 2013-08-07. PMID:23687119. |
in both murine and human samples, extracellular matrix metalloproteinase inducer was detected on endothelium in healthy and disease states but was dramatically increased in and around inflammatory perivascular cuffs on leucocytes, associated with matrix metalloproteinase expression, and on resident cells including microglia. |
2013-08-07 |
2023-08-12 |
human |
| Jingnan Pu, Wei Shi, Zizhang Wang, Ruizhi Wang, Zhenyu Guo, Chongxiao Liu, Jianjun Sun, Ligui Gao, Ren Zho. Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats. Journal of biomedical research. vol 25. issue 4. 2013-07-04. PMID:23554704. |
mc may inhibit the activation of microglia, the inflammatory reaction and factors, matrix metalloproteinases and apoptosis, thus protecting neurons. |
2013-07-04 |
2023-08-12 |
rat |
| Tamjeed A Siddiqui, Starlee Lively, Catherine Vincent, Lyanne C Schlichte. Regulation of podosome formation, microglial migration and invasion by Ca(2+)-signaling molecules expressed in podosomes. Journal of neuroinflammation. vol 9. 2013-07-01. PMID:23158496. |
microglia migrate during brain development and after cns injury, but it is not known how they degrade the extracellular matrix (ecm) to accomplish this. |
2013-07-01 |
2023-08-12 |
Not clear |
| Catherine Vincent, Tamjeed A Siddiqui, Lyanne C Schlichte. Podosomes in migrating microglia: components and matrix degradation. Journal of neuroinflammation. vol 9. 2013-06-10. PMID:22873355. |
podosomes in migrating microglia: components and matrix degradation. |
2013-06-10 |
2023-08-12 |
Not clear |
| Catherine Vincent, Tamjeed A Siddiqui, Lyanne C Schlichte. Podosomes in migrating microglia: components and matrix degradation. Journal of neuroinflammation. vol 9. 2013-06-10. PMID:22873355. |
to perform their functions during development and after central nervous system injury, the brain's immune cells (microglia) must migrate through dense neuropil and extracellular matrix (ecm), but it is not known how they degrade the ecm. |
2013-06-10 |
2023-08-12 |
Not clear |
| Onyou Hwan. Role of oxidative stress in Parkinson's disease. Experimental neurobiology. vol 22. issue 1. 2013-04-16. PMID:23585717. |
in addition, activated microglia produce nitric oxide and superoxide during neuroinflammatory responses, and this is aggravated by the molecules released by damaged daergic neurons such as α-synuclein, neuromelanin and matrix metalloproteinase-3. |
2013-04-16 |
2023-08-12 |
human |
| Katrin Kierdorf, Daniel Erny, Tobias Goldmann, Victor Sander, Christian Schulz, Elisa Gomez Perdiguero, Peter Wieghofer, Annette Heinrich, Pia Riemke, Christoph Hölscher, Dominik N Müller, Bruno Luckow, Thomas Brocker, Katharina Debowski, Günter Fritz, Ghislain Opdenakker, Andreas Diefenbach, Knut Biber, Mathias Heikenwalder, Frederic Geissmann, Frank Rosenbauer, Marco Prin. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nature neuroscience. vol 16. issue 3. 2013-04-09. PMID:23334579. |
proliferating a2 cells became microglia and invaded the developing brain using specific matrix metalloproteinases. |
2013-04-09 |
2023-08-12 |
mouse |