| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giulia Palermo, Ursula Rothlisberger, Andrea Cavalli, Marco De Viv. Computational insights into function and inhibition of fatty acid amide hydrolase. European journal of medicinal chemistry. vol 91. 2015-09-30. PMID:25240419. |
faah is a critical enzyme of the endocannabinoid system, being mainly responsible for regulating the level of its main cannabinoid substrate anandamide. |
2015-09-30 |
2023-08-13 |
Not clear |
| Ana Bernal-Chico, Manuel Canedo, Andrea Manterola, María Victoria Sánchez-Gómez, Alberto Pérez-Samartín, Rafael Rodríguez-Puertas, Carlos Matute, Susana Mat. Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo. Glia. vol 63. issue 1. 2015-09-14. PMID:25130621. |
here we show that the selective monoacylglycerol lipase (magl) inhibitor jzl184 suppressed cell death by mild activation of ampa receptors in oligodendrocytes in vitro, an effect that was mimicked by magl substrate 2-ag and by the second major endocannabinoid aea, in a concentration-dependent manner, whereas inhibition of the aea metabolizing enzyme fatty acid amide hydrolase with urb597 was devoid of effect. |
2015-09-14 |
2023-08-13 |
Not clear |
| Fabricio A Moreira, Bianca Jupp, David Belin, Jeffrey W Dalle. Endocannabinoids and striatal function: implications for addiction-related behaviours. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25369747. |
we highlight the potential of selective inhibitors of endocannabinoid metabolism, directed at fatty acid amide hydrolase and monoacylglycerol lipase, to reduce anxiety and stress responses, and discuss novel mechanisms underlying the modulation of the endocannabinoid system, including the attenuation of impulsivity, anxiety, and drug reward by selective cb2 receptor agonists. |
2015-09-03 |
2023-08-13 |
Not clear |
| Maddalena Mereu, Valeria Tronci, Lauren E Chun, Alexandra M Thomas, Jennifer L Green, Jonathan L Katz, Gianluigi Tand. Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice. Addiction biology. vol 20. issue 1. 2015-08-24. PMID:23910902. |
further, both behavioral and neurochemical cocaine sensitization were facilitated by pharmacological blockade of endocannabinoid metabolism, achieved by inhibiting the fatty acid amide hydrolase enzyme. |
2015-08-24 |
2023-08-12 |
mouse |
| Oscar Sasso, Marco Migliore, Damien Habrant, Andrea Armirotti, Clara Albani, Maria Summa, Guillermo Moreno-Sanz, Rita Scarpelli, Daniele Piomell. Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 6. 2015-08-24. PMID:25757568. |
fatty acid amide hydrolase (faah) degrades the endocannabinoid anandamide, which attenuates inflammation and promotes gi healing. |
2015-08-24 |
2023-08-13 |
mouse |
| b' A C Pascual, A M Mart\\xc3\\xadn-Moreno, N M Giusto, M L de Ceballos, S J Pasquar\\xc3\\xa. Normal aging in rats and pathological aging in human Alzheimer\'s disease decrease FAAH activity: modulation by cannabinoid agonists. Experimental gerontology. vol 60. 2015-08-19. PMID:25456842.' |
normal aging in rats and pathological aging in human alzheimer's disease decrease faah activity: modulation by cannabinoid agonists. |
2015-08-19 |
2023-08-13 |
human |
| Luciano R Vilela, Pedro H Gobira, Thercia G Viana, Daniel C Medeiros, Talita H Ferreira-Vieira, Juliana G Doria, Flávia Rodrigues, Daniele C Aguiar, Grace S Pereira, André R Massessini, Fabíola M Ribeiro, Antonio Carlos P de Oliveira, Marcio F D Moraes, Fabricio A Moreir. Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity. Toxicology and applied pharmacology. vol 286. issue 3. 2015-08-17. PMID:25933444. |
thus, we hypothesized that inhibition of fatty acid amide hydrolase (faah), the main enzyme responsible for terminating the actions of the endocannabinoid anandamide, reduces seizures and cell death in the hippocampus in a model of cocaine intoxication. |
2015-08-17 |
2023-08-13 |
mouse |
| Benjamin K Lau, Geoffrey M Drew, Vanessa A Mitchell, Christopher W Vaugha. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. British journal of pharmacology. vol 171. issue 23. 2015-08-14. PMID:25041240. |
endocannabinoid modulation by faah and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. |
2015-08-14 |
2023-08-13 |
Not clear |
| V Kiran Vemuri, A Makriyanni. Medicinal chemistry of cannabinoids. Clinical pharmacology and therapeutics. vol 97. issue 6. 2015-08-12. PMID:25801236. |
drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivating enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (mgl). |
2015-08-12 |
2023-08-13 |
Not clear |
| Eugene Krustev, Allison Reid, Jason J McDougal. Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints. Arthritis research & therapy. vol 16. issue 5. 2015-08-04. PMID:25260980. |
one enzyme responsible for endocannabinoid breakdown is fatty acid amide hydrolase (faah). |
2015-08-04 |
2023-08-13 |
mouse |
| Benjamin H Rotstein, Hsiao-Ying Wey, Timothy M Shoup, Alan A Wilson, Steven H Liang, Jacob M Hooker, Neil Vasde. PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates. Molecular pharmaceutics. vol 11. issue 11. 2015-08-03. PMID:25004399. |
fatty acid amide hydrolase (faah) regulates endocannabinoid signaling. |
2015-08-03 |
2023-08-13 |
human |
| Jason M Wiebelhaus, Travis W Grim, Robert A Owens, Matthew F Lazenka, Laura J Sim-Selley, Rehab A Abdullah, Micah J Niphakis, Robert E Vann, Benjamin F Cravatt, Jenny L Wiley, S Stevens Negus, Aron H Lichtma. Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice. The Journal of pharmacology and experimental therapeutics. vol 352. issue 2. 2015-07-08. PMID:25398241. |
in this study, we investigated the impact of thc and inhibitors of the endocannabinoid hydrolytic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) on operant responding for electrical stimulation of the medial forebrain bundle [intracranial self-stimulation (icss)], which is known to activate the mesolimbic dopamine system. |
2015-07-08 |
2023-08-13 |
mouse |
| Aldric T Hama, Peter Germano, Matthew S Varghese, Benjamin F Cravatt, G Todd Milne, James P Pearson, Jacqueline Sage. Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain. PloS one. vol 9. issue 5. 2015-06-23. PMID:24788435. |
increasing the endocannabinoid anandamide and other fatty acid amides (faa) by blocking fatty acid amide hydrolase (faah) has been shown to be antinociceptive in a number of animal models of chronic pain. |
2015-06-23 |
2023-08-13 |
rat |
| Travis W Grim, Sudeshna Ghosh, Ku-Lung Hsu, Benjamin F Cravatt, Steven G Kinsey, Aron H Lichtma. Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:25058512. |
however, recent preclinical data indicate that combined inhibition of cyclooxygenase (cox) and fatty acid amide hydrolase (faah), the primary catabolic enzyme of the endocannabinoid n-arachidonoylethanolamine (anandamide; aea), produces enhanced antinociceptive effects in a variety of murine models of pain. |
2015-05-19 |
2023-08-13 |
mouse |
| M Sałaga, A Mokrowiecka, P K Zakrzewski, A Cygankiewicz, E Leishman, M Sobczak, H Zatorski, E Małecka-Panas, R Kordek, M Storr, W M Krajewska, H B Bradshaw, J Fichn. Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH). Journal of Crohn's & colitis. vol 8. issue 9. 2015-05-14. PMID:24530133. |
experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (faah). |
2015-05-14 |
2023-08-12 |
mouse |
| M Sałaga, A Mokrowiecka, P K Zakrzewski, A Cygankiewicz, E Leishman, M Sobczak, H Zatorski, E Małecka-Panas, R Kordek, M Storr, W M Krajewska, H B Bradshaw, J Fichn. Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH). Journal of Crohn's & colitis. vol 8. issue 9. 2015-05-14. PMID:24530133. |
here we aimed to assess the anti-inflammatory action of the novel fatty acid amide hydrolase (faah) inhibitor pf-3845 and its effect on the endocannabinoid and related lipid metabolism during the course of experimental colitis. |
2015-05-14 |
2023-08-12 |
mouse |
| Luciano R Vilela, Daniel C Medeiros, Antonio Carlos P de Oliveira, Marcio F Moraes, Fabricio A Moreir. Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels. Basic & clinical pharmacology & toxicology. vol 115. issue 4. 2015-05-14. PMID:24674273. |
anticonvulsant effects of n-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (trpv1) channel blocker, on experimental seizures: the roles of cannabinoid cb1 receptors and trpv1 channels. |
2015-05-14 |
2023-08-12 |
mouse |
| J Megan Gray, Haley A Vecchiarelli, Maria Morena, Tiffany T Y Lee, Daniel J Hermanson, Alexander B Kim, Ryan J McLaughlin, Kowther I Hassan, Claudia Kühne, Carsten T Wotjak, Jan M Deussing, Sachin Patel, Matthew N Hil. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 9. 2015-05-01. PMID:25740517. |
specifically, we found that crh, through activation of the crh receptor type 1 (crhr1), evokes a rapid induction of the enzyme fatty acid amide hydrolase (faah), which causes a reduction in the endocannabinoid anandamide (aea), within the amygdala. |
2015-05-01 |
2023-08-13 |
mouse |
| Russell L Carr, Casey A Graves, Lee C Mangum, Carole A Nail, Matthew K Ros. Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition. Neurotoxicology. vol 43. 2015-04-17. PMID:24373905. |
we have previously reported that repeated exposure to cpf results in greater inhibition of fatty acid amide hydrolase (faah), the enzyme that metabolizes the endocannabinoid anandamide (aea), than inhibition of either forebrain che or monoacylglycerol lipase (magl), the enzyme that metabolizes the endocannabinoid 2-arachidonylglycerol (2-ag). |
2015-04-17 |
2023-08-12 |
rat |
| Patricia Rivera, Laura Bindila, Antoni Pastor, Margarita Pérez-Martín, Francisco J Pavón, Antonia Serrano, Rafael de la Torre, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Frontiers in cellular neuroscience. vol 9. 2015-04-14. PMID:25870539. |
the pharmacological effect of the fatty acid amide hydrolase (faah) inhibitor urb597, which limits the endocannabinoid degradation, was investigated in the present study. |
2015-04-14 |
2023-08-13 |
rat |