| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudius Füllhase, Andrea Russo, Fabio Castiglione, Fabio Benigni, Lysanne Campeau, Francesco Montorsi, Christian Gratzke, Arianna Bettiga, Christian Stief, Karl-Erik Andersson, Petter Hedlun. Spinal cord FAAH in normal micturition control and bladder overactivity in awake rats. The Journal of urology. vol 189. issue 6. 2013-07-17. PMID:23219540. |
we also determined the expression of faah, and the cannabinoid receptors cb1 and cb2 in the sacral spinal cord. |
2013-07-17 |
2023-08-12 |
rat |
| Javier Fernández-Ruiz, Onintza Sagredo, M Ruth Pazos, Concepción García, Roger Pertwee, Raphael Mechoulam, José Martínez-Orgad. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? British journal of clinical pharmacology. vol 75. issue 2. 2013-07-01. PMID:22625422. |
inhibition of faah enzyme), thereby enhancing the action of these endogenous molecules on cannabinoid receptors, which is also noted in certain pathological conditions. |
2013-07-01 |
2023-08-12 |
Not clear |
| Vinogran Naidoo, David A Karanian, Subramanian K Vadivel, Johnathan R Locklear, JodiAnne T Wood, Mahmoud Nasr, Pamela Marie P Quizon, Emily E Graves, Vidyanand Shukla, Alexandros Makriyannis, Ben A Bah. Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 9. issue 4. 2013-06-19. PMID:22270809. |
equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology. |
2013-06-19 |
2023-08-12 |
Not clear |
| Vinogran Naidoo, David A Karanian, Subramanian K Vadivel, Johnathan R Locklear, JodiAnne T Wood, Mahmoud Nasr, Pamela Marie P Quizon, Emily E Graves, Vidyanand Shukla, Alexandros Makriyannis, Ben A Bah. Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 9. issue 4. 2013-06-19. PMID:22270809. |
it is proposed that the influence of am6701 on faah and magl exerts a synergistic action on the endocannabinoid system, thereby promoting the protective nature of cannabinergic signaling to offset excitotoxic brain injury. |
2013-06-19 |
2023-08-12 |
Not clear |
| Christopher J Fowle. Transport of endocannabinoids across the plasma membrane and within the cell. The FEBS journal. vol 280. issue 9. 2013-06-18. PMID:23441874. |
intracellular carrier proteins that shuttle the endocannabinoid anandamide from the plasma membrane to its intracellular targets such as the metabolic enzyme, fatty acid amide hydrolase, have been identified. |
2013-06-18 |
2023-08-12 |
Not clear |
| Mandana Kianian, Nadia A Al-Banna, Melanie E M Kelly, Christian Lehman. Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut. Journal of basic and clinical physiology and pharmacology. vol 24. issue 1. 2013-06-17. PMID:23382309. |
our study aimed to examine intestinal leukocyte adhesion and capillary perfusion following selective inhibition of the endocannabinoid degradation enzyme, fatty acid amide hydrolase (faah), in experimental sepsis (endotoxemia). |
2013-06-17 |
2023-08-12 |
Not clear |
| Laura Bertolacci, Elisa Romeo, Marina Veronesi, Paola Magotti, Clara Albani, Mauro Dionisi, Chiara Lambruschini, Rita Scarpelli, Andrea Cavalli, Marco De Vivo, Daniele Piomelli, Gianpiero Gara. A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase. Journal of the American Chemical Society. vol 135. issue 1. 2013-06-05. PMID:23240907. |
in addition to inhibiting the cyclooxygenase (cox)-mediated biosynthesis of prostanoids, various widely used nonsteroidal anti-inflammatory drugs (nsaids) enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase (faah). |
2013-06-05 |
2023-08-12 |
Not clear |
| Josée Guindon, Yvonne Lai, Sara M Takacs, Heather B Bradshaw, Andrea G Hohman. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological research. vol 67. issue 1. 2013-05-23. PMID:23127915. |
effects of cisplatin on endocannabinoid levels and transcription of receptors (cb(1), cb(2), trpv1, trpa1) and enzymes (faah, mgl) linked to the endocannabinoid system were also assessed. |
2013-05-23 |
2023-08-12 |
Not clear |
| Josée Guindon, Yvonne Lai, Sara M Takacs, Heather B Bradshaw, Andrea G Hohman. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological research. vol 67. issue 1. 2013-05-23. PMID:23127915. |
the anti-allodynic effects of faah and mgl inhibitors are mediated by cb(1) and cb(2) cannabinoid receptors, whereas trpv1, but not trpa1, -dependent mechanisms contribute to the anti-allodynic efficacy of faah (but not mgl) inhibitors. |
2013-05-23 |
2023-08-12 |
Not clear |
| Josée Guindon, Yvonne Lai, Sara M Takacs, Heather B Bradshaw, Andrea G Hohman. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological research. vol 67. issue 1. 2013-05-23. PMID:23127915. |
thus, inhibition of endocannabinoid hydrolysis, via faah or mgl inhibitors, represents an efficacious pharmacological approach for suppressing chemotherapy-induced neuropathic pain. |
2013-05-23 |
2023-08-12 |
Not clear |
| Tiffany T-Y Lee, Matthew N Hill, Cecilia J Hillard, Boris B Gorzalk. Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. Synapse (New York, N.Y.). vol 67. issue 1. 2013-05-07. PMID:22987804. |
fatty acid amide hydrolase (faah) regulates tissue concentrations of n-acylethanolamines (naes), including the endocannabinoid, n-arachidonylethanolamide (anandamide, aea). |
2013-05-07 |
2023-08-12 |
rat |
| A M Sanchez, P Vigano, A Mugione, P Panina-Bordignon, M Candian. The molecular connections between the cannabinoid system and endometriosis. Molecular human reproduction. vol 18. issue 12. 2013-05-06. PMID:22923487. |
the components of the endocannabinoid system, cb1 and cb2 receptors and the enzymes n-acylphosphatidylethanolamine-phospholipase d and fatty acid amide hydrolase are differentially regulated throughout the menstrual cycle in the endometrium and are expressed in deep endometriotic nodules and in sensory and sympathetic neurons innervating the lesions. |
2013-05-06 |
2023-08-12 |
Not clear |
| Alpha K Gebeh, Jonathon M Willets, Monica Bari, Robert A Hirst, Timothy H Marczylo, Anthony H Taylor, Mauro Maccarrone, Justin C Konj. Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity. The Journal of clinical endocrinology and metabolism. vol 98. issue 3. 2013-04-30. PMID:23372171. |
studies from knockout mice suggest that perturbations in oviductal endocannabinoid levels, endocannabinoid receptors, or endocannabinoid degrading enzyme [fatty acid amide hydrolase (faah)] expression result in infertility secondary to physical trapping of embryos. |
2013-04-30 |
2023-08-12 |
mouse |
| Pablo M Rusjan, Alan A Wilson, Romina Mizrahi, Isabelle Boileau, Sofia E Chavez, Nancy J Lobaugh, Stephen J Kish, Sylvain Houle, Junchao Ton. Mapping human brain fatty acid amide hydrolase activity with PET. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 3. 2013-04-19. PMID:23211960. |
[(11)c]curb is the first available positron emission tomography (pet) radiotracer for imaging fatty acid amide hydrolase (faah), the enzyme which metabolizes the prominent endocannabinoid anandamide. |
2013-04-19 |
2023-08-12 |
human |
| Pretal P Muldoon, Aron H Lichtman, Loren H Parsons, M Imad Dama. The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:22705310. |
the endogenous cannabinoid anandamide (aea) exerts the majority of its effects at cb1 and cb2 receptors and is degraded by fatty acid amide hydrolase (faah). |
2013-04-17 |
2023-08-12 |
mouse |
| Pretal P Muldoon, Aron H Lichtman, Loren H Parsons, M Imad Dama. The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:22705310. |
in this mini review, we describe the functional consequences of faah inhibition on nicotine reward and dependence as well as the underlying endocannabinoid and non-cannabinoid receptor systems mediating these effects. |
2013-04-17 |
2023-08-12 |
mouse |
| Alan A Wilson, Justin W Hicks, Oleg Sadovski, Jun Parkes, Junchao Tong, Sylvain Houle, Christopher J Fowler, Neil Vasde. Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography. Journal of medicinal chemistry. vol 56. issue 1. 2013-04-17. PMID:23214511. |
fatty acid amide hydrolase (faah) plays a key role in regulating the tone of the endocannabinoid system. |
2013-04-17 |
2023-08-12 |
rat |
| Ludovica Morera, Geoffray Labar, Giorgio Ortar, Didier M Lamber. Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23036333. |
development and characterization of endocannabinoid hydrolases faah and magl inhibitors bearing a benzotriazol-1-yl carboxamide scaffold. |
2013-04-05 |
2023-08-12 |
human |
| Sébastien Lenglet, Aurélien Thomas, Oliver Soehnlein, Fabrizio Montecucco, Fabienne Burger, Graziano Pelli, Katia Galan, Benjamin Cravatt, Christian Staub, Sabine Steffen. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. Arteriosclerosis, thrombosis, and vascular biology. vol 33. issue 2. 2013-03-14. PMID:23241405. |
therefore, we studied the involvement of fatty acid amide hydrolase (faah) deficiency, the major enzyme responsible for endocannabinoid anandamide degradation, in atherosclerotic plaque vulnerability. |
2013-03-14 |
2023-08-12 |
mouse |
| Leonora E Long, Jonna Lind, Maree Webster, Cynthia Shannon Weicker. Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex. BMC neuroscience. vol 13. 2013-03-08. PMID:22827915. |
we used microarray with qpcr validation and in situ hybridisation to quantify mrna for the central endocannabinoid receptor cb(1)r, endocannabinoid synthetic enzymes (daglα for 2-arachidonylglycerol [2-ag] and nape-pld for anandamide), and inactivating enzymes (mgl and abhd6 for 2-ag and faah for anandamide) in human dorsolateral prefrontal cortex (39 days - 49 years). |
2013-03-08 |
2023-08-12 |
human |