| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mireille Alhouayek, Giulio G Mucciol. The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. Trends in molecular medicine. vol 18. issue 10. 2013-02-15. PMID:22917662. |
anandamide and 2-arachidonoylglycerol are endogenous bioactive lipids that bind to and activate the cannabinoid receptors, and together with the enzymes responsible for their biosynthesis and degradation [fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl)] constitute the endocannabinoid system (ecs). |
2013-02-15 |
2023-08-12 |
Not clear |
| Marc B Skaddan, Lei Zhang, Douglas S Johnson, Aijun Zhu, Kenneth R Zasadny, Richard V Coelho, Kyle Kuszpit, Gwen Currier, Kuo-Hsien Fan, Elizabeth M Beck, Laigao Chen, Susan E Drozda, Gayatri Balan, Micah Niphakis, Benjamin F Cravatt, Kay Ahn, Thomas Bocan, Anabella Villalobo. The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH). Nuclear medicine and biology. vol 39. issue 7. 2013-02-12. PMID:22571907. |
fatty acid amide hydrolase (faah) is responsible for the enzymatic degradation of the fatty acid amide family of signaling lipids, including the endogenous cannabinoid (endocannabinoid) anandamide. |
2013-02-12 |
2023-08-12 |
Not clear |
| Marc B Skaddan, Lei Zhang, Douglas S Johnson, Aijun Zhu, Kenneth R Zasadny, Richard V Coelho, Kyle Kuszpit, Gwen Currier, Kuo-Hsien Fan, Elizabeth M Beck, Laigao Chen, Susan E Drozda, Gayatri Balan, Micah Niphakis, Benjamin F Cravatt, Kay Ahn, Thomas Bocan, Anabella Villalobo. The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH). Nuclear medicine and biology. vol 39. issue 7. 2013-02-12. PMID:22571907. |
the involvement of the endocannabinoid system in pain and other nervous system disorders has made faah an attractive target for drug development. |
2013-02-12 |
2023-08-12 |
Not clear |
| Alonso Vilches-Flores, Astrid C Hauge-Evans, Peter M Jones, Shanta J Persau. Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function. Clinical science (London, England : 1979). vol 124. issue 7. 2013-02-11. PMID:23078523. |
quantitative rt-pcr (reverse transcription-pcr) indicated that mrnas encoding synthesis [nape-pld (n-acyl-phosphatidyl ethanolamide-hydrolysing phospholipase d)] and degradation [faah (fatty acid amide hydrolase)] of the endocannabinoid aea (anandamide) were the most abundant ecs elements in mouse islets, with much lower levels of cb1r, cb2r, dagl (diacylglycerol lipase) and magl (monoacylglycerol lipase) mrnas. |
2013-02-11 |
2023-08-12 |
mouse |
| M J Khan, D E Graugnard, J J Loo. Endocannabinoid system and proopiomelanocortin gene expression in peripartal bovine liver in response to prepartal plane of nutrition. Journal of animal physiology and animal nutrition. vol 96. issue 5. 2013-02-05. PMID:21812840. |
we examined mrna expression via qpcr of endocannabinoid receptors (cnr1 and cnr2), enzymes that synthesize fae (hrasls5 and n-acyl phosphatidylethanolamine phospholipase d), enzymes that degrade fae [fatty acid amide hydrolase (faah), n-acylethanolamine acid amidase (naaa) and monoglyceride lipase (mgll)], and the hormone precursor proopiomelanocortin (pomc) in liver at -14, 7, 14 and 30 days around parturition from cows fed with a control (con; ne(l) = 1.34 mcal/kg) or moderate-energy (over; ne(l) = 1.62 mcal/kg) diet during the dry period. |
2013-02-05 |
2023-08-12 |
cattle |
| Erica Butti, Marco Bacigaluppi, Silvia Rossi, Marco Cambiaghi, Monica Bari, Arantxa Cebrian Silla, Elena Brambilla, Alessandra Musella, Roberta De Ceglia, Luis Teneud, Valentina De Chiara, Patrizia D'Adamo, Jose Manuel Garcia-Verdugo, Giancarlo Comi, Luca Muzio, Angelo Quattrini, Letizia Leocani, Mauro Maccarrone, Diego Centonze, Gianvito Martin. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain : a journal of neurology. vol 135. issue Pt 11. 2013-02-04. PMID:23008234. |
in vivo restoration of cannabinoid levels, either by administration of the type 1 cannabinoid receptor agonist hu210 or the inhibitor of the principal catabolic enzyme fatty acid amide hydrolase, urb597, completely reverted the increased morbidity and mortality of adult neural stem and progenitor cell-ablated mice suffering from epilepsy and ischaemic stroke. |
2013-02-04 |
2023-08-12 |
mouse |
| Marina Mitjans, Cristóbal Gastó, Rosa Catalán, Lourdes Fañanás, Bárbara Aria. Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes. Journal of psychopharmacology (Oxford, England). vol 26. issue 10. 2013-01-30. PMID:22826533. |
genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the cnr1, cnr2 and faah genes. |
2013-01-30 |
2023-08-12 |
Not clear |
| Marina Mitjans, Cristóbal Gastó, Rosa Catalán, Lourdes Fañanás, Bárbara Aria. Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes. Journal of psychopharmacology (Oxford, England). vol 26. issue 10. 2013-01-30. PMID:22826533. |
given the evidence for the role of the endocannabinoid system in the pathogenesis of depression as well as in the mediation of antidepressant drug effects, the aim of this study was to analyze genetic variability in the endocannabinoid system genes (cnr1, cnr2 and faah genes) and their role in clinical response (at week 4) and remission (at week 12) in ssri (citalopram) treatment in a sample of 154 depressive outpatients, all of spanish origin. |
2013-01-30 |
2023-08-12 |
Not clear |
| Joel E Schlosburg, Lilyana Radanova, Vincenzo Di Marzo, Peter Imming, Aron H Lichtma. Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice. Behavioural pharmacology. vol 23. issue 7. 2013-01-29. PMID:22954646. |
two novel arachidonoyl-conjugated metabolites are formed in mice following the administration of dipyrone that are dependent on the activity of fatty acid amide hydrolase (faah), which also represents the major catabolic enzyme of the endogenous cannabinoid ligand anandamide. |
2013-01-29 |
2023-08-12 |
mouse |
| Joel E Schlosburg, Lilyana Radanova, Vincenzo Di Marzo, Peter Imming, Aron H Lichtma. Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice. Behavioural pharmacology. vol 23. issue 7. 2013-01-29. PMID:22954646. |
the relative contributions of cannabinoid receptors and faah in the overall behavioral response to dipyrone remain untested. |
2013-01-29 |
2023-08-12 |
mouse |
| Bright N Okine, Leonie M Norris, Stephen Woodhams, James Burston, Annie Patel, Stephen P H Alexander, David A Barrett, David A Kendall, Andrew J Bennett, Victoria Chapma. Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. British journal of pharmacology. vol 167. issue 3. 2013-01-17. PMID:22595021. |
lack of effect of chronic pre-treatment with the faah inhibitor urb597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. |
2013-01-17 |
2023-08-12 |
Not clear |
| Bright N Okine, Leonie M Norris, Stephen Woodhams, James Burston, Annie Patel, Stephen P H Alexander, David A Barrett, David A Kendall, Andrew J Bennett, Victoria Chapma. Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. British journal of pharmacology. vol 167. issue 3. 2013-01-17. PMID:22595021. |
elevating levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (faah) is a major focus of pain research, purported to be a safer approach devoid of cannabinoid receptor-mediated side effects. |
2013-01-17 |
2023-08-12 |
Not clear |
| D A de Luis, R Aller, O Izaola, R Conde, M Gonzalez Sagrado, D Primo, M J Castr. Relationship among metabolic syndrome, C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance. Journal of diabetes and its complications. vol 26. issue 4. 2013-01-14. PMID:22609216. |
relationship among metabolic syndrome, c358a polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) and insulin resistance. |
2013-01-14 |
2023-08-12 |
Not clear |
| Antonio Caprioli, Roberto Coccurello, Cinzia Rapino, Stefano Di Serio, Monia Di Tommaso, Mario Vertechy, Valentina Vacca, Natalia Battista, Flaminia Pavone, Mauro Maccarrone, Franco Borsin. The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. The Journal of pharmacology and experimental therapeutics. vol 342. issue 1. 2012-11-26. PMID:22514334. |
the novel reversible fatty acid amide hydrolase inhibitor st4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. |
2012-11-26 |
2023-08-12 |
mouse |
| Laurence L Miller, Mitchell J Picker, Michael D Umberger, Karl T Schmidt, Linda A Dykstr. Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. The Journal of pharmacology and experimental therapeutics. vol 342. issue 1. 2012-11-26. PMID:22514333. |
inhibitors of fatty acid amide hydrolase (faah) and anandamide (aea) uptake, which limit the degradation of endogenous cannabinoids, have received interest as potential therapeutics for pain. |
2012-11-26 |
2023-08-12 |
mouse |
| Laurence L Miller, Mitchell J Picker, Michael D Umberger, Karl T Schmidt, Linda A Dykstr. Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. The Journal of pharmacology and experimental therapeutics. vol 342. issue 1. 2012-11-26. PMID:22514333. |
using such procedures, this study examines the effects of the direct cannabinoid type 1 (cb1) agonist (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol (cp55940), the faah inhibitor cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester (urb597), and the aea uptake inhibitor n-(4-hydroxyphenyl) arachidonylamide (am404). |
2012-11-26 |
2023-08-12 |
mouse |
| Stefania Butini, Margherita Brindisi, Sandra Gemma, Patrizia Minetti, Walter Cabri, Grazia Gallo, Silvia Vincenti, Emanuela Talamonti, Franco Borsini, Antonio Caprioli, Maria Antonietta Stasi, Stefano Di Serio, Sindu Ros, Giuseppe Borrelli, Samuele Maramai, Filomena Fezza, Giuseppe Campiani, Mauro Maccarron. Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases. Journal of medicinal chemistry. vol 55. issue 15. 2012-11-05. PMID:22779702. |
fatty acid amide hydrolase (faah, ec 3.5.1.99) is the main enzyme catabolizing endocannabinoid fatty acid amides. |
2012-11-05 |
2023-08-12 |
mouse |
| Stefania Butini, Margherita Brindisi, Sandra Gemma, Patrizia Minetti, Walter Cabri, Grazia Gallo, Silvia Vincenti, Emanuela Talamonti, Franco Borsini, Antonio Caprioli, Maria Antonietta Stasi, Stefano Di Serio, Sindu Ros, Giuseppe Borrelli, Samuele Maramai, Filomena Fezza, Giuseppe Campiani, Mauro Maccarron. Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases. Journal of medicinal chemistry. vol 55. issue 15. 2012-11-05. PMID:22779702. |
faah inactivation promotes beneficial effects upon pain and anxiety without the side effects accompanying agonists of type-1 cannabinoid receptors. |
2012-11-05 |
2023-08-12 |
mouse |
| Alessia Ligresti, Rosaria Villano, Marco Allarà, István Ujváry, Vincenzo Di Marz. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand. Pharmacological research. vol 66. issue 2. 2012-10-25. PMID:22525682. |
these compounds were investigated for assessing their cannabinoid receptor binding affinity and capability of inhibiting the activity of the two major metabolic enzymes of the endocannabinoid system, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2012-10-25 |
2023-08-12 |
human |
| Cristina Benito, Rosa María Tolón, Ana Isabel Castillo, Lourdes Ruiz-Valdepeñas, José Antonio Martínez-Orgado, Francisco Javier Fernández-Sánchez, Carmen Vázquez, Benjamin F Cravatt, Julián Romer. β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors. British journal of pharmacology. vol 166. issue 4. 2012-10-09. PMID:22321194. |
one experimental approach is the enhancement of endocannabinoid tone by blocking the activity of degradative enzymes, such as fatty acid amide hydrolase (faah). |
2012-10-09 |
2023-08-12 |
Not clear |