| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuqi Xie, Abdolsamad Borazjani, M Jason Hatfield, Carol C Edwards, Philip M Potter, Matthew K Ros. Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. Chemical research in toxicology. vol 23. issue 12. 2012-03-20. PMID:21049984. |
collectively, the results suggest that in addition to magl and fatty-acid amide hydrolase (faah), which have both been documented to terminate endocannabinoid signaling, ces may also have a role. |
2012-03-20 |
2023-08-12 |
human |
| Islam Gamaleddin, Mihail Guranda, Steven R Goldberg, Bernard Le Fol. The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake. British journal of pharmacology. vol 164. issue 6. 2012-03-08. PMID:21501143. |
faah hydrolyses the endogenous endocannabinoid anandamide, as well as other non-cannabinoid ligands such as oleoylethanolamide (oea) and palmitoylethanolamide (pea). |
2012-03-08 |
2023-08-12 |
Not clear |
| Alessio Lodola, Silvia Rivara, Marco Mo. Application of computational methods to the design of fatty acid amide hydrolase (FAAH) inhibitors based on a carbamic template structure. Advances in protein chemistry and structural biology. vol 85. 2012-02-07. PMID:21920320. |
fatty acid amide hydrolase (faah) is a key component of the endocannabinoid system and a potential drug target for several therapeutic applications. |
2012-02-07 |
2023-08-12 |
Not clear |
| Ish K Khanna, Christopher W Alexande. Fatty acid amide hydrolase inhibitors--progress and potential. CNS & neurological disorders drug targets. vol 10. issue 5. 2012-02-03. PMID:21631410. |
fatty acid amide hydrolase (faah) is responsible for hydrolysis of endocannabinoid, anandamide (aea), and n-acyl ethanolamines such as palmitoylethanolamine (pea) and n-oleoylethanolamide (oea). |
2012-02-03 |
2023-08-12 |
Not clear |
| Robin D Clugston, Hongfeng Jiang, Man Xia Lee, Roseann Piantedosi, Jason J Yuen, Rajasekhar Ramakrishnan, Michael J Lewis, Max E Gottesman, Li-Shin Huang, Ira J Goldberg, Paul D Berk, William S Blane. Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. Journal of lipid research. vol 52. issue 11. 2012-02-02. PMID:21856784. |
alcohol feeding was associated with i) increased hepatic free fatty acid levels and decreased fatty acyl-coa levels associated with decreased mitochondrial fatty acid oxidation and decreased fatty acyl-coa synthesis, respectively; ii) increased hepatic ceramide levels associated with higher levels of the precursor molecules sphingosine and sphinganine; and iii) increased hepatic levels of the endocannabinoid anandamide associated with decreased expression of its catabolic enzyme fatty acid amide hydrolase. |
2012-02-02 |
2023-08-12 |
mouse |
| Marvin J Meyers, Scott A Long, Matthew J Pelc, Jane L Wang, Scott J Bowen, Barbara A Schweitzer, Mark V Wilcox, Joseph McDonald, Sarah E Smith, Susan Foltin, Jeanne Rumsey, Young-Sun Yang, Mark C Walker, Satwik Kamtekar, David Beidler, Atli Thorarense. Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain. Bioorganic & medicinal chemistry letters. vol 21. issue 21. 2012-01-31. PMID:21924613. |
fatty acid amide hydrolase (faah) is an integral membrane serine hydrolase responsible for the degradation of fatty acid amide signaling molecules such as endocannabinoid anandamide (aea), which has been shown to possess cannabinoid-like analgesic properties. |
2012-01-31 |
2023-08-12 |
Not clear |
| Seul Ki Lim, Min Jung Park, Jae Cheong Lim, Jong Choon Kim, Ho Jae Han, Gye-Yeop Kim, Benjamin F Cravatt, Chang Hoon Woo, Seung Jin Ma, Kyung Cheol Yoon, Soo Hyun Par. Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells. Journal of cellular physiology. vol 227. issue 2. 2012-01-30. PMID:21442624. |
fatty acid amide hydrolase (faah), the enzyme responsible for the degradation of the main endocannabinoid, anandamide, and related fatty acid amides, has emerged as a regulator of endocannabinoid signaling. |
2012-01-30 |
2023-08-12 |
human |
| Tongjian You, Beth L Disanzo, Xuewen Wang, Rongze Yang, Dawei Gon. Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise. Lipids in health and disease. vol 10. 2012-01-26. PMID:22035053. |
the purpose of this study was to determine whether gene expression levels of cannabinoid type 1 receptor (cb1) and fatty acid amide hydrolase (faah) are different in subcutaneous abdominal and gluteal adipose tissue, and whether hypocaloric diet and aerobic exercise influence subcutaneous adipose tissue cb1 and faah gene expression in obese women. |
2012-01-26 |
2023-08-12 |
Not clear |
| Guillermo Moreno-Sanz, Borja Barrera, Ana Guijarro, Ilaria d'Elia, Jon Andoni Otero, Ana I Alvarez, Tiziano Bandiera, Gracia Merino, Daniele Piomell. The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacological research. vol 64. issue 4. 2012-01-19. PMID:21767647. |
the o-arylcarbamate urb937 is a potent inhibitor of fatty-acid amide hydrolase (faah), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. |
2012-01-19 |
2023-08-12 |
mouse |
| Linda A Parker, Erin M Rock, Cheryl L Limebee. Regulation of nausea and vomiting by cannabinoids. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21175589. |
cannabinoid agonists (Δ(9) -thc, hu-210) and the fatty acid amide hydrolase (faah) inhibitor, urb-597, suppress conditioned gaping reactions (nausea) in rats as they suppress vomiting in emetic species. |
2012-01-18 |
2023-08-12 |
mouse |
| J Suárez, O Ortíz, N Puente, F J Bermúdez-Silva, E Blanco, P Fernández-Llebrez, P Grandes, F Rodríguez de Fonseca, R Moratall. Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain. Neuroscience. vol 192. 2012-01-18. PMID:21756982. |
we discuss our comparative analysis of the forebrain expression patterns of daglα and other components of the endocannabinoid signaling system, including the cb(1) receptor, monoacylglyceride lipase (magl), and fatty acid amide hydrolase (faah), providing some insight into the potential physiological and behavioral roles of this system. |
2012-01-18 |
2023-08-12 |
mouse |
| Arnab Banerjee, Ajit Singh, Puneet Srivastava, Helen Turner, Amitabh Krishn. Effects of chronic bhang (cannabis) administration on the reproductive system of male mice. Birth defects research. Part B, Developmental and reproductive toxicology. vol 92. issue 3. 2012-01-09. PMID:21678546. |
an attempt was also made to investigate the presence of cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptors, and fatty acid amide hydrolase (faah) in the testis and to evaluate any changes in it resulting from chronic intake of bhang in mice. |
2012-01-09 |
2023-08-12 |
mouse |
| Chitra Sridar, Natasha T Snider, Paul F Hollenber. Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 5. 2011-12-30. PMID:21289075. |
thus, the current findings provide potential new insights into the actions of inhibitors faah and eh, which are being developed as novel therapeutic agents, as well as a better understanding of the interactions between the cytochrome p450 monooxygenases and the endocannabinoid system. |
2011-12-30 |
2023-08-12 |
human |
| Clay W Scott, Gaochao Tian, Xiao Hong Yu, Kathy A Paschetto, Dee E Wilkins, Luc Meury, Chang Qing Cao, Jeffrey Varnes, Philip D Edward. Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase. European journal of pharmacology. vol 667. issue 1-3. 2011-12-27. PMID:21645511. |
fatty acid amide hydrolase (faah) hydrolyzes several bioactive lipids including the endocannabinoid anandamide. |
2011-12-27 |
2023-08-12 |
human |
| Clay W Scott, Gaochao Tian, Xiao Hong Yu, Kathy A Paschetto, Dee E Wilkins, Luc Meury, Chang Qing Cao, Jeffrey Varnes, Philip D Edward. Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase. European journal of pharmacology. vol 667. issue 1-3. 2011-12-27. PMID:21645511. |
in this native tissue assay of synaptic activity, az513 reduced epscs, which is consistent with inhibiting endogenous faah and augmenting endocannabinoid tone. |
2011-12-27 |
2023-08-12 |
human |
| D Minocci, J Massei, A Martino, M Milianti, L Piz, D Di Bello, A Sbrana, E Martinotti, A M Rossi, P Nier. Genetic association between bipolar disorder and 524A>C (Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor. Journal of affective disorders. vol 134. issue 1-3. 2011-12-21. PMID:21658778. |
several studies provided evidence that the endocannabinoid system (ecs) is involved in psychiatric diseases, like major depression, schizophrenia and bipolar disorder (bd), mainly focusing on cb1 cannabinoid receptor, and faah, the fatty acid amide hydrolase involved in endocannabinoid metabolism. |
2011-12-21 |
2023-08-12 |
Not clear |
| Marion Feledziak, Giulio G Muccioli, Didier M Lambert, Jacqueline Marchand-Brynaer. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process. Journal of medicinal chemistry. vol 54. issue 19. 2011-12-12. PMID:21899370. |
the endocannabinoid hydrolyzing enzyme faah uses a nonclassical catalytic triad (namely, ser-ser-lys instead of ser-asp-his) to cleave its endogenous substrates. |
2011-12-12 |
2023-08-12 |
mouse |
| Steven G Kinsey, Pattipati S Naidu, Benjamin F Cravatt, David T Dudley, Aron H Lichtma. Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21740924. |
fatty acid amide hydrolase (faah) is the primary degradative enzyme of the endocannabinoid anandamide (n-arachidonoylethanolamine), which activates cannabinoid cb(1) and cb(2) receptors. |
2011-12-09 |
2023-08-12 |
mouse |
| Steven G Kinsey, Pattipati S Naidu, Benjamin F Cravatt, David T Dudley, Aron H Lichtma. Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21740924. |
the observed anti-arthritic and anti-hyperalgesic properties of faah inhibition, coupled with a lack of apparent behavioral alterations, suggest that endocannabinoid modulating enzymes offer a promising therapeutic target for the development of novel pharmacological approaches to treat rheumatoid arthritis and associated hyperalgesia. |
2011-12-09 |
2023-08-12 |
mouse |
| Silvia Rossi, Roberto Furlan, Valentina De Chiara, Luca Muzio, Alessandra Musella, Caterina Motta, Valeria Studer, Francesca Cavasinni, Giorgio Bernardi, Gianvito Martino, Benjamin F Cravatt, Beat Lutz, Mauro Maccarrone, Diego Centonz. Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. Brain, behavior, and immunity. vol 25. issue 6. 2011-12-07. PMID:21473912. |
consistently, we found that mice lacking the fatty acid amide hydrolase (faah), and thus expressing abnormally high brain levels of the endocannabinoid anandamide, developed a less severe eae associated with preserved tnfα-induced sepsc alterations. |
2011-12-07 |
2023-08-12 |
mouse |