| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Dowie, M L Howard, L F B Nicholson, R L M Faull, A J Hannan, M Glas. Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice. Neuroscience. vol 170. issue 1. 2011-05-24. PMID:20600638. |
molecular characterisation of brains at the end of the study showed that there were no significant effects of hu210 or thc treatment on the ligand binding of cannabinoid cb1, dopamine d1, d2, serotonin 5ht2a or gaba(a) receptors, nor cb1 or fatty acid amide hydrolase (faah) mrna expression in r6/1 mice. |
2011-05-24 |
2023-08-12 |
mouse |
| Partha Mukhopadhyay, Bėla Horváth, Mohanraj Rajesh, Shingo Matsumoto, Keita Saito, Sándor Bátkai, Vivek Patel, Galin Tanchian, Rachel Y Gao, Benjamin F Cravatt, György Haskó, Pál Pache. Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury. Free radical biology & medicine. vol 50. issue 1. 2011-05-09. PMID:21070851. |
we have investigated the role of the main endocannabinoid anandamide-metabolizing enzyme (fatty acid amide hydrolase; faah) in myocardial injury induced by an important chemotherapeutic drug, doxorubicin (dox; known for its cardiotoxicity mediated by increased reactive oxygen and nitrogen species generation), using well-established acute and chronic cardiomyopathy models in mice. |
2011-05-09 |
2023-08-12 |
mouse |
| Jonathan Z Long, Melanie LaCava, Xin Jin, Benjamin F Cravat. An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase. Journal of lipid research. vol 52. issue 2. 2011-05-05. PMID:21097653. |
fatty acid amide hydrolase (faah) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its n-acyl ethanolamine (nae) congeners and transient receptor potential channel agonists n-acyl taurines (nats). |
2011-05-05 |
2023-08-12 |
mouse |
| Anna Minkkilä, Susanna Saario, Tapio Nevalaine. Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. Current topics in medicinal chemistry. vol 10. issue 8. 2011-05-02. PMID:20370710. |
fatty acid amide hydrolase (faah) and monoglyceride lipase (mgl) are hydrolytic enzymes which degrade the endogenous cannabinoids (endocannabinoids) n-arachidonoylethanolamine (anandamide, aea) and 2-arachidonoylglycerol (2-ag), respectively. |
2011-05-02 |
2023-08-12 |
Not clear |
| Steven G Kinsey, Jonathan Z Long, Benjamin F Cravatt, Aron H Lichtma. Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms. The journal of pain. vol 11. issue 12. 2011-03-21. PMID:20554481. |
in conclusion, although endogenous cannabinoids do not appear to play a tonic role in long-term expression of neuropathic pain states, both faah and magl represent potential therapeutic targets for the development of pharmacological agents to treat chronic pain resulting from nerve injury. |
2011-03-21 |
2023-08-12 |
mouse |
| Grzegorz Godlewski, Shakiru O Alapafuja, Sándor Bátkai, Spyros P Nikas, Resat Cinar, László Offertáler, Douglas Osei-Hyiaman, Jie Liu, Bani Mukhopadhyay, Judith Harvey-White, Joseph Tam, Karel Pacak, Jacqueline L Blankman, Benjamin F Cravatt, Alexandros Makriyannis, George Kuno. Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chemistry & biology. vol 17. issue 11. 2011-03-14. PMID:21095576. |
the enzyme fatty acid amide hydrolase (faah) catalyzes the in vivo degradation of the endocannabinoid anandamide, thus controlling its action at receptors. |
2011-03-14 |
2023-08-12 |
mouse |
| Andri Evagorou, Dimitrios Anagnostopoulos, Elena Farmaki, Athanasia Siafaka-Kapada. Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme. European journal of protistology. vol 46. issue 4. 2011-03-09. PMID:20889319. |
previous studies from our group showed that tetrahymena contains major components of the endocannabinoid system, such as various endocannabinoids and faah. |
2011-03-09 |
2023-08-12 |
Not clear |
| D A de Luis, M Gonzalez Sagrado, D Pacheco, M C Terroba, T Martin, L Cuellar, M Ventos. Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss and cardiovascular risk factors 1 year after biliopancreatic diversion surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. vol 6. issue 5. 2011-02-04. PMID:20870184. |
effects of c358a missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss and cardiovascular risk factors 1 year after biliopancreatic diversion surgery. |
2011-02-04 |
2023-08-12 |
Not clear |
| Gaurav Bhatia, Vikas Bansal, Olivier Harismendy, Nicholas J Schork, Eric J Topol, Kelly Frazer, Vineet Bafn. A covering method for detecting genetic associations between rare variants and common phenotypes. PLoS computational biology. vol 6. issue 10. 2011-01-28. PMID:20976246. |
individual samples were re-sequenced at two genes, faah and mgll, known to be involved in endocannabinoid metabolism (187kbp for 148 obese and 150 controls). |
2011-01-28 |
2023-08-12 |
Not clear |
| R Greco, V Gasperi, G Sandrini, G Bagetta, G Nappi, M Maccarrone, C Tassorell. Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat. Cephalalgia : an international journal of headache. vol 30. issue 3. 2011-01-20. PMID:19515121. |
the medulla, the mesencephalon and the hypothalamus were dissected out and utilized for the evaluation of activity of fatty acid amide hydrolase (that degrades the endocannabinoid anandamide), monoacylglycerol lipase (that degrades the endocannabinoid 2-arachidonoylglycerol), and binding sites specific for cannabinoid (cb) receptors. |
2011-01-20 |
2023-08-12 |
rat |
| Marco Mor, Alessio Lodol. Pharmacological tools in endocannabinoid neurobiology. Current topics in behavioral neurosciences. vol 1. 2011-01-04. PMID:21104381. |
as for compounds affecting endocannabinoid levels in living tissues, many classes of selective and, in some cases, drug-like inhibitors of faah are available, while only compounds with poor selectivity or in vivo activity are known to inhibit other enzymes involved in endocannabinoid catabolism, such as naaa or mgl, and in endocannabinoid biosynthesis. |
2011-01-04 |
2023-08-12 |
Not clear |
| Amanda L McCallum, Cheryl L Limebeer, Linda A Parke. Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance. Pharmacology, biochemistry, and behavior. vol 96. issue 4. 2010-12-23. PMID:20643159. |
reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, urb597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance. |
2010-12-23 |
2023-08-12 |
rat |
| Sonia Gattinoni, Chiara De Simone, Sabrina Dallavalle, Filomena Fezza, Raffaella Nannei, Natalia Battista, Patrizia Minetti, Gianandrea Quattrociocchi, Antonio Caprioli, Franco Borsini, Walter Cabri, Sergio Penco, Lucio Merlini, Mauro Maccarron. A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. Bioorganic & medicinal chemistry letters. vol 20. issue 15. 2010-11-23. PMID:20591666. |
a series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (faah), an important regulatory enzyme of the endocannabinoid signaling system. |
2010-11-23 |
2023-08-12 |
Not clear |
| Sonia Gattinoni, Chiara De Simone, Sabrina Dallavalle, Filomena Fezza, Raffaella Nannei, Natalia Battista, Patrizia Minetti, Gianandrea Quattrociocchi, Antonio Caprioli, Franco Borsini, Walter Cabri, Sergio Penco, Lucio Merlini, Mauro Maccarron. A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. Bioorganic & medicinal chemistry letters. vol 20. issue 15. 2010-11-23. PMID:20591666. |
kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for faah over the other components of the endocannabinoid system. |
2010-11-23 |
2023-08-12 |
Not clear |
| Lina Thors, Anders Bergh, Emma Persson, Peter Hammarsten, Pär Stattin, Lars Egevad, Torvald Granfors, Christopher J Fowle. Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808855. |
here we have investigated the expression of the endocannabinoid metabolising enzyme fatty acid amide hydrolase (faah) in a well characterised tissue microarray from patients diagnosed with prostate cancer at transurethral resection for voiding problems. |
2010-11-04 |
2023-08-12 |
Not clear |
| Palmiero Monteleone, Walter Milano, Claudio Petrella, Benedetta Canestrelli, Mario Ma. Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain. Journal of clinical psychopharmacology. vol 30. issue 4. 2010-11-03. PMID:20631561. |
endocannabinoid pro129thr faah functional polymorphism but not 1359g/a cnr1 polymorphism is associated with antipsychotic-induced weight gain. |
2010-11-03 |
2023-08-12 |
human |
| Palmiero Monteleone, Walter Milano, Claudio Petrella, Benedetta Canestrelli, Mario Ma. Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain. Journal of clinical psychopharmacology. vol 30. issue 4. 2010-11-03. PMID:20631561. |
therefore, we investigated the 1359 g/a (rs1049353) single nucleotide polymorphisms (snp) of the cannabinoid receptor 1 (cnr1) gene, which codes the endocannabinoid cb1 receptor, and the complementary dna (cdna) 385c/a (rs324420) snp of the faah gene, which codes the endocannabinoid degrading enzyme, for their role in bw changes induced by antipsychotic drugs. |
2010-11-03 |
2023-08-12 |
human |
| Antonio Luchicchi, Salvatore Lecca, Stefano Carta, Giuliano Pillolla, Anna L Muntoni, Sevil Yasar, Steven R Goldberg, Marco Pisti. Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors. Addiction biology. vol 15. issue 3. 2010-11-02. PMID:20477753. |
we recently demonstrated that inhibition by urb597 of fatty acid amide hydrolase (faah), the main enzyme that degrades the endogenous cannabinoid n-acylethanolamine (nae) anandamide and the endogenous non-cannabinoid naes oleoylethanolamide and palmitoylethanolamide, blocks nicotine-induced excitation of ventral tegmental area (vta) dopamine (da) neurons and da release in the shell of the nucleus accumbens (shnac), as well as nicotine-induced drug self-administration, conditioned place preference and relapse in rats. |
2010-11-02 |
2023-08-12 |
rat |
| Sherry Shu-Jung Hu, Andy Arnold, Jacqueline M Hutchens, Josh Radicke, Benjamin F Cravatt, Jim Wager-Miller, Ken Mackie, Alex Straike. Architecture of cannabinoid signaling in mouse retina. The Journal of comparative neurology. vol 518. issue 18. 2010-10-25. PMID:20653038. |
here we show the localization of diacylglycerol lipase-alpha and -beta (dglalpha/beta), implicated in the production of the ecb 2-arachidonoyl glycerol (2-ag); monoacylglycerol lipase (mgl) and alpha/beta-hydrolase domain 6 (abhd6), both implicated in the breakdown of 2-ag; cannabinoid receptor-interacting protein 1a (crip1a), a protein that may modulate cb(1) function; and fatty acid amide hydrolase (faah) and n-acylethanolamine-hydrolyzing acid amidase (naaa), which have been shown to break down the ecb anandamide and related acyl amides. |
2010-10-25 |
2023-08-12 |
mouse |
| Jason R Clapper, Guillermo Moreno-Sanz, Roberto Russo, Ana Guijarro, Federica Vacondio, Andrea Duranti, Andrea Tontini, Silvano Sanchini, Natale R Sciolino, Jessica M Spradley, Andrea G Hohmann, Antonio Calignano, Marco Mor, Giorgio Tarzia, Daniele Piomell. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nature neuroscience. vol 13. issue 10. 2010-10-20. PMID:20852626. |
to address this question, we developed a peripherally restricted inhibitor (urb937) of fatty acid amide hydrolase (faah), the enzyme responsible for the degradation of the endocannabinoid anandamide. |
2010-10-20 |
2023-08-12 |
Not clear |