| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica M Spradley, Josée Guindon, Andrea G Hohman. Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. Pharmacological research. vol 62. issue 3. 2010-10-18. PMID:20416378. |
we compared effects of the mgl inhibitor jzl184, the faah inhibitor urb597, and the endocannabinoid uptake inhibitor vdm11, administered locally in the paw, on behavioral hypersensitivities produced by capsaicin, the pungent ingredient in hot chili peppers. |
2010-10-18 |
2023-08-12 |
rat |
| Jessica M Spradley, Josée Guindon, Andrea G Hohman. Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. Pharmacological research. vol 62. issue 3. 2010-10-18. PMID:20416378. |
inhibition of endocannabinoid transport was more effective in suppressing capsaicin-induced sensitization compared to inhibition of either faah or mgl alone. |
2010-10-18 |
2023-08-12 |
rat |
| Jessica M Spradley, Josée Guindon, Andrea G Hohman. Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. Pharmacological research. vol 62. issue 3. 2010-10-18. PMID:20416378. |
our data suggest that 2-ag, the putative product of mgl inhibition, and aea, the putative product of faah inhibition, differentially suppress capsaicin-induced nociception through peripheral cannabinoid mechanisms. |
2010-10-18 |
2023-08-12 |
rat |
| L Thors, J J Burston, B J Alter, M K McKinney, B F Cravatt, R A Ross, R G Pertwee, R W Gereau, J L Wiley, C J Fowle. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. British journal of pharmacology. vol 160. issue 3. 2010-10-14. PMID:20590565. |
inhibitors of fatty acid amide hydrolase (faah), the enzyme responsible for the metabolism of the endogenous cannabinoid (cb) receptor ligand anandamide (aea), are effective in a number of animal models of pain. |
2010-10-14 |
2023-08-12 |
Not clear |
| Leonie Wyffels, Giulio G Muccioli, Coco N Kapanda, Geoffray Labar, Sylvie De Bruyne, Filip De Vos, Didier M Lamber. PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue. Nuclear medicine and biology. vol 37. issue 5. 2010-10-14. PMID:20610171. |
fatty acid amide hydrolase (faah) is part of the endocannabinoid system (ecs) and has been linked to the aetiology of several neurological and neuropsychiatric disorders. |
2010-10-14 |
2023-08-12 |
Not clear |
| P Bagavandoss, S Grimsha. Temporal and spatial distribution of the cannabinoid receptors (CB1, CB2) and fatty acid amide hydroxylase in the rat ovary. Anatomical record (Hoboken, N.J. : 2007). vol 293. issue 8. 2010-10-13. PMID:20665820. |
evidence also suggests that the concentration of the endocannabinoid anandamide is regulated by cellular fatty acid amide hydrolase (faah). |
2010-10-13 |
2023-08-12 |
rat |
| Joel E Schlosburg, Jacqueline L Blankman, Jonathan Z Long, Daniel K Nomura, Bin Pan, Steven G Kinsey, Peter T Nguyen, Divya Ramesh, Lamont Booker, James J Burston, Elizabeth A Thomas, Dana E Selley, Laura J Sim-Selley, Qing-song Liu, Aron H Lichtman, Benjamin F Cravat. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nature neuroscience. vol 13. issue 9. 2010-10-04. PMID:20729846. |
these data contrast with blockade of fatty acid amide hydrolase, an enzyme that degrades the other major endocannabinoid anandamide, which produced sustained analgesia without impairing cb1 receptors. |
2010-10-04 |
2023-08-12 |
mouse |
| Iain Brown, Maria G Cascio, Klaus W J Wahle, Reem Smoum, Raphael Mechoulam, Ruth A Ross, Roger G Pertwee, Steven D Hey. Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis. vol 31. issue 9. 2010-09-30. PMID:20660502. |
our findings suggest that the expression of cannabinoid receptors and of faah in some tumour cells could well influence the effectiveness of dha and epa or their ethanolamide derivatives as anticancer agents. |
2010-09-30 |
2023-08-12 |
Not clear |
| S Y Sit, Charles M Conway, Kai Xie, Robert Bertekap, Clotilde Bourin, Kevin D Burri. Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorganic & medicinal chemistry letters. vol 20. issue 3. 2010-09-20. PMID:20036536. |
a series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (faah). |
2010-09-20 |
2023-08-12 |
Not clear |
| Katherine W Falenski, Andrew J Thorpe, Joel E Schlosburg, Benjamin F Cravatt, Rehab A Abdullah, Tricia H Smith, Dana E Selley, Aron H Lichtman, Laura J Sim-Selle. FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 8. 2010-09-17. PMID:20357755. |
however, the consequences of repeated administration of the endocannabinoid n-arachidonoyl ethanolamine (anandamide, aea) on cannabinoid receptor regulation are unclear because of its rapid metabolism by fatty acid amide hydrolase (faah). |
2010-09-17 |
2023-08-12 |
mouse |
| Andrea M Dlugos, Ajna Hamidovic, Colin A Hodgkinson, David Goldman, Abraham A Palmer, Harriet de Wi. More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19890266. |
amphetamine's effects are known to be modulated by endogenous cannabinoids, which are degraded by the enzyme fatty acid amide hydrolase (faah). |
2010-09-07 |
2023-08-12 |
human |
| Silvia Rossi, Valentina De Chiara, Alessandra Musella, Lucia Sacchetti, Cristina Cantarella, Maura Castelli, Francesca Cavasinni, Caterina Motta, Valeria Studer, Giorgio Bernardi, Benjamin F Cravatt, Mauro Maccarrone, Alessandro Usiello, Diego Centonz. Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition. Molecular pharmacology. vol 78. issue 2. 2010-08-03. PMID:20424126. |
preservation of striatal cannabinoid cb1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition. |
2010-08-03 |
2023-08-12 |
mouse |
| Silvia Rossi, Valentina De Chiara, Alessandra Musella, Lucia Sacchetti, Cristina Cantarella, Maura Castelli, Francesca Cavasinni, Caterina Motta, Valeria Studer, Giorgio Bernardi, Benjamin F Cravatt, Mauro Maccarrone, Alessandro Usiello, Diego Centonz. Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition. Molecular pharmacology. vol 78. issue 2. 2010-08-03. PMID:20424126. |
the endocannabinoid anandamide (aea) plays a crucial role in emotional control, and inhibition of its degradation by the fatty acid amide hydrolase (faah) has a potent antianxiety effect. |
2010-08-03 |
2023-08-12 |
mouse |
| Silvia Rossi, Valentina De Chiara, Alessandra Musella, Lucia Sacchetti, Cristina Cantarella, Maura Castelli, Francesca Cavasinni, Caterina Motta, Valeria Studer, Giorgio Bernardi, Benjamin F Cravatt, Mauro Maccarrone, Alessandro Usiello, Diego Centonz. Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition. Molecular pharmacology. vol 78. issue 2. 2010-08-03. PMID:20424126. |
by using faah mutant mice and both intraperitoneal and intracerebroventricular administration of the faah inhibitor (3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl)-cyclohexylcarbamate (urb597), we found that enhanced aea signaling reversed, via central cannabinoid cb1 receptors (cb1rs), the anxious phenotype of mice exposed to social defeat stress. |
2010-08-03 |
2023-08-12 |
mouse |
| Silvia Rossi, Valentina De Chiara, Alessandra Musella, Lucia Sacchetti, Cristina Cantarella, Maura Castelli, Francesca Cavasinni, Caterina Motta, Valeria Studer, Giorgio Bernardi, Benjamin F Cravatt, Mauro Maccarrone, Alessandro Usiello, Diego Centonz. Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition. Molecular pharmacology. vol 78. issue 2. 2010-08-03. PMID:20424126. |
collectively, our findings suggest that preservation of cannabinoid cb1 receptor function within the striatum is a possible synaptic correlate of the antianxiety effects of faah inhibition. |
2010-08-03 |
2023-08-12 |
mouse |
| Dimitris Anagnostopoulos, Carmelina Rakiec, Jodi Wood, Lakshmipathi Pandarinathan, Nikolai Zvonok, Alexandros Makriyannis, Athanasia Siafaka-Kapada. Identification of endocannabinoids and related N-acylethanolamines in tetrahymena. A new class of compounds for Tetrahymena. Protist. vol 161. issue 3. 2010-07-22. PMID:20096629. |
we reported that major components of the endocannabinoid system such as fatty acid amide hydrolase and monoacylglycerol lipase, are present in the protist tetrahymena, with characteristics similar to those in mammals. |
2010-07-22 |
2023-08-12 |
Not clear |
| Pattipati S Naidu, Steven G Kinsey, Tai L Guo, Benjamin F Cravatt, Aron H Lichtma. Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase. The Journal of pharmacology and experimental therapeutics. vol 334. issue 1. 2010-07-13. PMID:20375198. |
conversely, fatty acid amide hydrolase (faah), the chief catabolic enzyme regulating the endogenous cannabinoid n-arachidonoylethanolamine (anandamide), has emerged as an attractive target for treating pain and other conditions. |
2010-07-13 |
2023-08-12 |
mouse |
| Palmiero Monteleone, Maurizio Bifulco, Giuseppe Maina, Alfonso Tortorella, Patrizia Gazzerro, Maria Chiara Proto, Carmela Di Filippo, Francesco Monteleone, Benedetta Canestrelli, Giovanna Buonerba, Filippo Bogetto, Mario Ma. Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacological research. vol 61. issue 5. 2010-07-05. PMID:20080186. |
investigation of cnr1 and faah endocannabinoid gene polymorphisms in bipolar disorder and major depression. |
2010-07-05 |
2023-08-12 |
human |
| D A de Luis, M Gonzalez Sagrado, R Aller, O Izaola, R Conde, E Romer. C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2. Diabetes research and clinical practice. vol 88. issue 1. 2010-06-28. PMID:20056290. |
c358a missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) and insulin resistance in patients with diabetes mellitus type 2. |
2010-06-28 |
2023-08-12 |
Not clear |
| Alexandre Seillier, Tushar Advani, Tommaso Cassano, Julie G Hensler, Andrea Giuffrid. Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats. The international journal of neuropsychopharmacology. vol 13. issue 3. 2010-06-24. PMID:19607756. |
taken together, these results suggest that faah inhibition may improve negative symptoms in pcp-treated rats but produce deleterious effects in untreated animals, possibly by disturbing endocannabinoid tone. |
2010-06-24 |
2023-08-12 |
rat |