| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmen Mazzola, Julie Medalie, Maria Scherma, Leigh V Panlilio, Marcello Solinas, Gianluigi Tanda, Filippo Drago, Jean Lud Cadet, Steven R Goldberg, Sevil Yasa. Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors. Learning & memory (Cold Spring Harbor, N.Y.). vol 16. issue 5. 2009-07-15. PMID:19403796. |
inhibitors of fatty acid amide hydrolase (faah) increase endogenous levels of anandamide (a cannabinoid cb(1)-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (oea and pea, ligands for alpha-type peroxisome proliferator-activated nuclear receptors, ppar-alpha) when and where they are naturally released in the brain. |
2009-07-15 |
2023-08-12 |
rat |
| Varadarajan Sudhahar, Sean Shaw, John D Imi. Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19326479. |
in agreement with the vascular functional data, the cannabinoid cb1 and trpv1 receptor proteins were expressed in mesenteric resistance arteries but cannabinoid cb2 receptors and the faah enzyme were not. |
2009-07-07 |
2023-08-12 |
rat |
| M Storr, D Emmerdinger, J Diegelmann, B Yüce, S Pfennig, T Ochsenkühn, B Göke, P Lohse, S Bran. The role of fatty acid hydrolase gene variants in inflammatory bowel disease. Alimentary pharmacology & therapeutics. vol 29. issue 5. 2009-07-06. PMID:19053981. |
recent studies suggest a role for the endocannabinoid system, including fatty acid amide hydrolase (faah), in intestinal inflammation. |
2009-07-06 |
2023-08-12 |
Not clear |
| J A Palmer, E S Higuera, L Chang, S R Chapla. Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18541380. |
the implications of this model in the study of pain in mice, and the therapeutic potential of faah inhibition to provide analgesia without the undesirable side effects of direct agonism of cannabinoid receptors are discussed. |
2009-06-29 |
2023-08-12 |
mouse |
| Kay Ahn, Douglas S Johnson, Mauro Mileni, David Beidler, Jonathan Z Long, Michele K McKinney, Eranthie Weerapana, Nalini Sadagopan, Marya Liimatta, Sarah E Smith, Scott Lazerwith, Cory Stiff, Satwik Kamtekar, Keshab Bhattacharya, Yanhua Zhang, Stephen Swaney, Keri Van Becelaere, Raymond C Stevens, Benjamin F Cravat. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & biology. vol 16. issue 4. 2009-06-19. PMID:19389627. |
the endocannabinoid anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (faah), and there is currently much interest in developing faah inhibitors to augment endocannabinoid signaling in vivo. |
2009-06-19 |
2023-08-12 |
Not clear |
| Kay Ahn, Douglas S Johnson, Mauro Mileni, David Beidler, Jonathan Z Long, Michele K McKinney, Eranthie Weerapana, Nalini Sadagopan, Marya Liimatta, Sarah E Smith, Scott Lazerwith, Cory Stiff, Satwik Kamtekar, Keshab Bhattacharya, Yanhua Zhang, Stephen Swaney, Keri Van Becelaere, Raymond C Stevens, Benjamin F Cravat. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & biology. vol 16. issue 4. 2009-06-19. PMID:19389627. |
pf-3845 selectively inhibits faah in vivo, as determined by activity-based protein profiling; raises brain anandamide levels for up to 24 hr; and produces significant cannabinoid receptor-dependent reductions in inflammatory pain. |
2009-06-19 |
2023-08-12 |
Not clear |
| María Gracia Gervasi, Maximiliano Rapanelli, María Laura Ribeiro, Mariana Farina, Silvia Billi, Ana María Franchi, Silvina Perez Martine. The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. Reproduction (Cambridge, England). vol 137. issue 3. 2009-06-15. PMID:19042982. |
we observed that bull sperm and bovine oviductal epithelial cells express cannabinoid receptors, cb1 and cb2, and fatty acid amide hydrolase, the enzyme that controls intracellular anandamide levels. |
2009-06-15 |
2023-08-12 |
cattle |
| Wolfgang Lieb, Alisa K Manning, Jose C Florez, Josée Dupuis, L Adrienne Cupples, Jarred B McAteer, Ramachandran S Vasan, Udo Hoffmann, Christopher J O'Donnell, James B Meigs, Caroline S Fo. Variants in the CNR1 and the FAAH genes and adiposity traits in the community. Obesity (Silver Spring, Md.). vol 17. issue 4. 2009-06-04. PMID:19165169. |
we hypothesize that common genetic variants in the cnr1 (encoding endocannabinoid receptor 1) and faah genes (encoding fatty acid amide hydrolase, a key enzyme hydrolyzing endocannabinoids) are associated with adiposity traits. |
2009-06-04 |
2023-08-12 |
human |
| Tiziana Antonelli, Maria Cristina Tomasini, Roberta Mazza, Kjell Fuxe, Silvana Gaetani, Vincenzo Cuomo, Sergio Tanganelli, Luca Ferrar. Cannabinoid CB1 and cholecystokinin CCK2 receptors modulate, in an opposing way, electrically evoked [3H]GABA efflux from rat cerebral cortex cell cultures: possible relevance for cortical GABA transmission and anxiety. The Journal of pharmacology and experimental therapeutics. vol 329. issue 2. 2009-05-22. PMID:19197005. |
the effects of treatments with cannabinoid (cb)(1) and cholecystokinin (cck)(2) receptor agonists and antagonists, as well as compounds that enhance endocannabinoid signaling by inhibiting degradation, e.g., the fatty acid amide hydrolase inhibitor 3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate (urb597) or the endocannabinoid reuptake inhibitor (5z,8z,11z,14z)-n-(3-furanylmethyl)-5,8,11,14-eicosatetraenamide (ucm707), were studied both on spontaneous and electrically evoked [(3)h]gaba efflux from rat cerebral cortex cell cultures. |
2009-05-22 |
2023-08-12 |
rat |
| Marina Rubio, Rosario de Miguel, Javier Fernández-Ruiz, Dolores Gutiérrez-López, Mauro A M Carai, José A Ramo. Effects of a short-term exposure to alcohol in rats on FAAH enzyme and CB1 receptor in different brain areas. Drug and alcohol dependence. vol 99. issue 1-3. 2009-05-21. PMID:18922654. |
in the present study, we wanted to further explore: (i) whether these decreases might be caused by an increase in fatty acid amide hydrolase (faah), the enzyme involved in the degradation of n-acylethanolamines including anandamide, and (ii) whether the changes in endocannabinoid levels are accompanied by parallel changes in the major cannabinoid receptor type, the cb(1) receptor, activated by these ligands in the brain. |
2009-05-21 |
2023-08-12 |
rat |
| Angelo A Izzo, Gabriella Aviello, Stefania Petrosino, Pierangelo Orlando, Giovanni Marsicano, Beat Lutz, Francesca Borrelli, Raffaele Capasso, Santosh Nigam, Francesco Capasso, Vincenzo Di Marz. Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. Journal of molecular medicine (Berlin, Germany). vol 86. issue 1. 2009-05-11. PMID:17823781. |
acf were induced by azoxymethane (aom); fatty acid amide hydrolase (faah) and cannabinoid receptor messenger ribonucleic acid (mrna) levels were analyzed by the quantitative reverse transcription polymerase chain reaction (rt-pcr); endocannabinoid levels were measured by liquid chromatography-mass spectrometry; caspase-3 and caspase-9 expressions were measured by western blot analysis. |
2009-05-11 |
2023-08-12 |
mouse |
| Angelo A Izzo, Gabriella Aviello, Stefania Petrosino, Pierangelo Orlando, Giovanni Marsicano, Beat Lutz, Francesca Borrelli, Raffaele Capasso, Santosh Nigam, Francesco Capasso, Vincenzo Di Marz. Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. Journal of molecular medicine (Berlin, Germany). vol 86. issue 1. 2009-05-11. PMID:17823781. |
the faah inhibitor n-arachidonoylserotonin increased colon endocannabinoid levels, reduced acf formation, and partially normalized cleaved caspase-3 (but not caspase-9) expression. |
2009-05-11 |
2023-08-12 |
mouse |
| C J Fowler, P S Naidu, A Lichtman, V Onni. The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. British journal of pharmacology. vol 156. issue 3. 2009-05-08. PMID:19226258. |
compounds inhibiting the enzyme fatty acid amide hydrolase (faah), by increasing local endocannabinoid tone, produce potentially useful effects in models of inflammatory and possibly neuropathic pain. |
2009-05-08 |
2023-08-12 |
Not clear |
| C J Fowler, P S Naidu, A Lichtman, V Onni. The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. British journal of pharmacology. vol 156. issue 3. 2009-05-08. PMID:19226258. |
local increases in levels of the endocannabinoid anandamide potentiate the actions of cyclooxygenase inhibitors, raising the possibility that compounds inhibiting both faah and cyclooxygenase can be as effective as non-steroidal anti-inflammatory drugs but with a reduced cyclooxygenase inhibitory 'load'. |
2009-05-08 |
2023-08-12 |
Not clear |
| Joel E Schlosburg, Dale L Boger, Benjamin F Cravatt, Aron H Lichtma. Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19168707. |
complementary genetic and pharmacological approaches to target fatty acid amide hydrolase (faah), the primary enzyme responsible for the degradation of the endocannabinoid anandamide, were evaluated in the compound 48/80 model. |
2009-04-28 |
2023-08-12 |
mouse |
| Christophe Mallet, Laurence Daulhac, Jérôme Bonnefont, Catherine Ledent, Monique Etienne, Eric Chapuy, Frédéric Libert, Alain Eschalie. Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia. Pain. vol 139. issue 1. 2009-04-21. PMID:18485596. |
accordingly with these results, we also demonstrated that the inhibition of faah, an enzyme involved in the cerebral metabolism of acetaminophen into am404, known to reinforce the activity of the endocannabinoid system, suppressed the antinociceptive effect of acetaminophen. |
2009-04-21 |
2023-08-12 |
mouse |
| Ben Coomber, Michael F O'Donoghue, Robert Maso. Inhibition of endocannabinoid metabolism attenuates enhanced hippocampal neuronal activity induced by kainic acid. Synapse (New York, N.Y.). vol 62. issue 10. 2009-04-21. PMID:18651640. |
the effects of inhibiting fatty acid amide hydrolase (faah), the enzyme responsible for metabolism of the endocannabinoid anandamide, on kainic acid (ka)-induced neuronal activity were investigated in the rat in vivo, using the selective faah inhibitor urb597. |
2009-04-21 |
2023-08-12 |
rat |
| Ryan K Butler, Kieran Rea, Yvonne Lang, Aisling M Gavin, David P Fin. Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: opioid receptor dependency and molecular correlates. Pain. vol 140. issue 3. 2009-04-17. PMID:19004548. |
administration of the fatty acid amide hydrolase and endocannabinoid catabolism inhibitor, urb597 (0.3 mg/kg, i.p. |
2009-04-17 |
2023-08-12 |
rat |
| Jason R Clapper, Regina A Mangieri, Daniele Piomell. The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18691603. |
in this article, we review evidence suggesting that (i) cannabis influences brain endocannabinoid signaling and (ii) faah inhibitors such as urb597 might offer a possible therapeutic avenue for the treatment of cannabis withdrawal. |
2009-04-15 |
2023-08-12 |
Not clear |
| F Rossi, D Siniscalco, L Luongo, L De Petrocellis, G Bellini, S Petrosino, M Torella, C Santoro, B Nobili, S Perrotta, V Di Marzo, S Maion. The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption. Bone. vol 44. issue 3. 2009-04-06. PMID:19059369. |
here, we examined the co-expression of the transient receptor potential vanilloid type 1 (trpv1) and the cannabinoid cb1/cb2 receptors together with n-acylphosphatidylethanolamine-hydrolizing phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts. |
2009-04-06 |
2023-08-12 |
mouse |