| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pinja Leimuranta, Leonard Khiroug, Rashid Giniatulli. Emerging Role of (Endo)Cannabinoids in Migraine. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29740328. |
individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ecs) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive cb1 and cb2 and pro-nociceptive trpv1 receptors. |
2020-09-30 |
2023-08-13 |
Not clear |
| Helmut Dahlhaus, Walburga Hanekamp, Matthias Leh. (Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH). MedChemComm. vol 8. issue 3. 2020-09-30. PMID:30108777. |
a series of phenyl 4-[(indol-1-yl)alkyl]piperidine carbamates was synthesized and tested for inhibition of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) and for metabolic stability in rat liver s9 fractions and porcine blood plasma. |
2020-09-30 |
2023-08-13 |
rat |
| Sean D Kodani, Debin Wan, Karen M Wagner, Sung Hee Hwang, Christophe Morisseau, Bruce D Hammoc. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. ACS omega. vol 3. issue 10. 2020-09-30. PMID:30411058. |
fatty acid amide hydrolase (faah) is responsible for regulating concentrations of the endocannabinoid arachidonoyl ethanolamide. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jiayong Yang, Yifeng Tian, Ruihe Zheng, Lei Li, Funan Qi. Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma. Oncology letters. vol 18. issue 2. 2020-09-30. PMID:31423220. |
anandamide (aea), the major endocannabinoid, was reduced in tumor tissues, probably due to the high expression and activity of fatty acid amide hydrolase. |
2020-09-30 |
2023-08-13 |
human |
| Thangesweran Ayakannu, Anthony H Taylor, Monica Bari, Nicoletta Mastrangelo, Mauro Maccarrone, Justin C Konj. Expression and Function of the Endocannabinoid Modulating Enzymes Fatty Acid Amide Hydrolase and Frontiers in oncology. vol 9. 2020-09-30. PMID:31921630. |
expression and function of the endocannabinoid modulating enzymes fatty acid amide hydrolase and |
2020-09-30 |
2023-08-13 |
Not clear |
| Nathan J Kolla, Achal Mishr. The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders. Frontiers in behavioral neuroscience. vol 12. 2020-09-29. PMID:29636670. |
the first main objective of this review is to dissect components of the endocannabinoid system, including cannabinoid 1 and cannabinoid 2 receptors; the endogenous cannabinoids anandamide and 2-arachidonoylglycerol; and the indirect cannabinoid modulators fatty acid amide hydrolase and monoacylglycerol lipase; that have shown abnormalities in basic research studies investigating mechanisms of aggression. |
2020-09-29 |
2023-08-13 |
human |
| Paula Morales, Nadine Jagerovi. Antitumor Cannabinoid Chemotypes: Structural Insights. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31214034. |
cannabinoids of endogenous, phytogenic, and synthetic nature have been shown to impact the proliferation of cancer through the modulation of different proteins involved in the endocannabinoid system such as the g protein-coupled receptors cb1, cb2, and grp55, the ionotropic receptor trpv1, or the fatty acid amide hydrolase (faah). |
2020-09-29 |
2023-08-13 |
Not clear |
| Abhilash Perisetti, Afrina Hossain Rimu, Salman Ali Khan, Pardeep Bansal, Hemant Goya. Role of cannabis in inflammatory bowel diseases. Annals of gastroenterology. vol 33. issue 2. 2020-09-28. PMID:32127734. |
endogenous circulating cannabinoids, or endocannabinoids, such as anandamide and 2-arachidonoyl-glycerol, their metabolizing enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) and 2 g-protein coupled cannabinoid receptors, cb1 and cb2, together represent the endocannabinoid system and are present throughout the human body. |
2020-09-28 |
2023-08-13 |
human |
| Manjunath Lamani, Michael S Malamas, Shrouq I Farah, Vidyanand G Shukla, Michael F Almeida, Catherine M Weerts, Joseph Anderson, JodiAnne T Wood, Karen L G Farizatto, Ben A Bahr, Alexandros Makriyanni. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & medicinal chemistry. vol 27. issue 23. 2020-09-24. PMID:31629610. |
faah is an enzyme implicated in the hydrolysis of the endocannabinoid n-arachidonoylethanolamine (aea), which is a partial agonist of the cb1 receptor. |
2020-09-24 |
2023-08-13 |
human |
| Manjunath Lamani, Michael S Malamas, Shrouq I Farah, Vidyanand G Shukla, Michael F Almeida, Catherine M Weerts, Joseph Anderson, JodiAnne T Wood, Karen L G Farizatto, Ben A Bahr, Alexandros Makriyanni. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & medicinal chemistry. vol 27. issue 23. 2020-09-24. PMID:31629610. |
the new inhibitors showed potent nanomolar inhibitory activity against human recombinant and purified rat faah, were selective (>1000-fold) against serine hydrolases mgl and abhd6 and lacked any affinity for the cannabinoid receptors cb1 and cb2. |
2020-09-24 |
2023-08-13 |
human |
| Ishnoor Kaur, Tapan Behl, Simona Bungau, Gokhan Zengin, Arun Kumar, Mohamed A El-Esawi, Gaurav Khullar, Thangavel Venkatachalam, Sandeep Aror. The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis. Life sciences. vol 257. 2020-09-17. PMID:32698072. |
the review also focuses on enhancement of endocannabinoid tone, either by inhibiting the degradation enzymes, like faah, magl, cox, cytp450, lox, etc. |
2020-09-17 |
2023-08-13 |
Not clear |
| Marie Fitzgibbon, Daniel M Kerr, Rebecca J Henry, David P Finn, Michelle Roch. Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31505257. |
furthermore, repeated ifn-α and/or formalin administration did not alter mrna expression of genes encoding the endocannabinoid catabolic enzymes (fatty acid amide hydrolase or monoacylglycerol lipase) or endocannabinoid receptor targets (cb |
2020-09-16 |
2023-08-13 |
mouse |
| Tomoteru Yamasaki, Tomoyuki Ohya, Wakana Mori, Yiding Zhang, Hidekatsu Wakizaka, Nobuki Nengaki, Masayuki Fujinaga, Tatsuya Kikuchi, Ming-Rong Zhan. Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer [ The Journal of pharmacology and experimental therapeutics. vol 373. issue 3. 2020-09-10. PMID:32241809. |
development of an in vivo method to estimate effective drug doses and quantify fatty acid amide hydrolase in rodent brain using positron emission tomography tracer [ fatty acid amide hydrolase (faah) is a key enzyme in the endocannabinoid system. |
2020-09-10 |
2023-08-13 |
Not clear |
| Ashleigh L Osborne, Nadia Solowij, Ilijana Babic, Jeremy S Lum, Kelly A Newell, Xu-Feng Huang, Katrina Weston-Gree. Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-26. PMID:31202911. |
conversely, cbd did not affect n-methyl-d-aspartate receptor and gamma-aminobutyric acid (gaba) a receptor binding or protein levels of fatty acid amide hydrolase, the enzyme that degrades the endocannabinoid, anandamide. |
2020-08-26 |
2023-08-13 |
rat |
| Je-Oh Lim, Je-Won Ko, Na-Rae Shin, Tae-Yang Jung, Changjong Moon, Hyoung-Chin Kim, In-Sik Shin, Jong-Choon Ki. Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system. Archives of toxicology. vol 93. issue 8. 2020-08-03. PMID:31256211. |
in addition, a cannabinoid 1 receptor agonist and faah inhibitor attenuated apoptosis and er stress, while cisplatin increased the binding of prmt3 with faah1. |
2020-08-03 |
2023-08-13 |
mouse |
| Leonardo Brunetti, Fulvio Loiodice, Luca Piemontese, Paolo Tortorella, Antonio Laghezz. New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation. Journal of medicinal chemistry. vol 62. issue 24. 2020-06-22. PMID:31407888. |
fatty acid amide hydrolase (faah) hydrolyzes the endocannabinoid anandamide and other |
2020-06-22 |
2023-08-13 |
Not clear |
| Alice Hartmann, Aline Fassini, América Scopinho, Fernando Ma Correa, Francisco S Guimarães, Sabrina F Lisboa, Leonardo Bm Resste. Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats. Journal of psychopharmacology (Oxford, England). vol 33. issue 5. 2020-06-12. PMID:30789299. |
the endocannabinoid anandamide activates cannabinoid type 1 receptors and is metabolized by the fatty acid amide hydrolase enzyme. |
2020-06-12 |
2023-08-13 |
rat |
| Jia Sun, Ya-Qun Zhou, Shu-Ping Chen, Xiao-Mei Wang, Bing-Yang Xu, Dan-Yang Li, Yu-Ke Tian, Da-Wei Y. The endocannabinoid system: Novel targets for treating cancer induced bone pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-23. PMID:31627091. |
targeting non-selective cannabinoid 1 receptors or selective cannabinoid 2 receptors, and modulation of peripheral aea and 2-ag, as well as the inhibition the function of fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) have produced analgesic effects in animal models of cibp. |
2020-04-23 |
2023-08-13 |
Not clear |
| Tina Zimmermann, Julia C Bartsch, Annika Beer, Ermelinda Lomazzo, Stephan Guggenhuber, Maren D Lange, Laura Bindila, Hans-Christian Pape, Beat Lut. Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30532004. |
this approach led to specific faah overexpression at the postsynaptic site of ca1-ca3 neurons, to increased faah enzymatic activity, and, in consequence, to decreased hippocampal levels of aea and palmitoylethanolamide (pea), but the levels of the second major endocannabinoid 2-arachidonoyl glycerol (2-ag) and of oleoylethanolamide (oea) were unchanged. |
2020-03-31 |
2023-08-13 |
mouse |
| Abir T El-Alfy, Ehab A Abourashed, Christina Patel, Nunmoula Mazhari, HeaRe An, Andrew Jeo. Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase. The Journal of pharmacy and pharmacology. vol 71. issue 12. 2020-03-27. PMID:31595522. |
the study aimed to identify nutmeg compounds that indirectly interact with the endocannabinoid system through inhibition of the fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) enzymes. |
2020-03-27 |
2023-08-13 |
Not clear |